Biologic Scaffolds for Regenerative Medicine: Mechanisms of In vivo Remodeling
Biologic Scaffolds for Regenerative Medicine: Mechanisms of In vivo Remodeling
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DOI：
10.1007/s10439-014-1103-8
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发表时间：
2015-03-01
影响因子：
3.8
通讯作者：
Badylak, Stephen F.
中科院分区：
文献类型：
--
作者：
Londono, Ricardo;Badylak, Stephen F.
用于功能性组织重建的成功的再生医学策略包括原位放置由细胞外基质（ECM）或ECM的单个组分组成的无细胞材料。这些材料的组成和超微结构取决于多种因素，包括材料收获的组织来源和物种、制造方法、去细胞化效率、后处理修饰如化学交联或溶解以及最终灭菌方法。适当配置的材料具有通过诱导从炎症和瘢痕组织形成的过程转变为结构性重塑和功能性组织恢复的过程来调节愈合反应的不同阶段的能力。在生物材料-宿主相互作用期间促进这种戏剧性变化的事件是复杂的，并且必然涉及免疫系统和干细胞募集、生长和分化的机制。本文综述了生物支架的组成、制造方法和建议、生物材料与宿主相互作用的机制以及这种再生医学方法的临床应用。
Successful regenerative medicine strategies for functional tissue reconstruction include the in situ placement of acellular materials composed of the extracellular matrix (ECM) or individual components of the ECM. The composition and ultrastructure of these materials vary depending on multiple factors including the tissue source and species from which the materials are harvested, the methods of manufacture, the efficiency of decellularization, post-processing modifications such as chemical cross-linking or solubilization, and the methods of terminal sterilization. Appropriately configured materials have the ability to modulate different stages of the healing response by inducing a shift from a process of inflammation and scar tissue formation to one of constructive remodeling and functional tissue restoration. The events that facilitate such a dramatic change during the biomaterial-host interaction are complex and necessarily involve both the immune system and mechanisms of stem cell recruitment, growth, and differentiation. The present manuscript reviews the composition of biologic scaffolds, the methods and recommendations for manufacture, the mechanisms of the biomaterial-host interaction, and the clinical application of this regenerative medicine approach.