A Mathematical Model Predicting Gliding Speed of Actin Molecular Shuttles Over Myosin Motors in the Presence of Defective Motors
A Mathematical Model Predicting Gliding Speed of Actin Molecular Shuttles Over Myosin Motors in the Presence of Defective Motors
复制标题
预测存在缺陷电机时肌动蛋白分子梭在肌球蛋白电机上滑动速度的数学模型
DOI：
10.1007/978-3-030-92163-7_17
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Nitta Takahiro
中科院分区：
文献类型：
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作者：
Kang’iri Samuel Macharia;Nitta Takahiro
马达蛋白是在活细胞中运行的分子机器。这些马达蛋白已在体外用于诸如纳米和微米级器件的应用，如生物传感器、生物计算和分子通信中的运输系统。通过将马达蛋白引入这些装置中，马达蛋白由于与装置表面的不利结合而变得有缺陷，导致运输速度降低或运输故障。然而，有缺陷的电机的影响的系统的实验研究受到阻碍的表面上的缺陷电机的数量控制的困难。在这里，我们展示了一个系统的研究，有缺陷的电机上的运动性的运输的影响，通过使用一个数学模型。该模型预测，运动性是独立的相关细丝的长度，并取决于主动马达的比例。该模型表明，超过80%的主动马达的比例是需要可持续的运动。这种见解将是有用的，在选择合适的材料与马达蛋白集成的设备。
Motor proteins are molecular machines that operate in living cells. These motor proteins have been used in vitro for applications such as nano- and microscale devices as transport systems in biosensors, biocomputing, and molecular communication. By introducing motor proteins into these devices, motor proteins become defective due to unfavorable binding to device surfaces, causing a decrease in transport speed or malfunctioning of transport. However, systematic experimental investigations of the effects of defective motors are hampered by difficulties in controlling the number of defective motors on surfaces. Here, we show a systematic study on the effects of defective motors on the motility of transport by using a mathematical model. The model predicted that motility is independent of the length of the associated filaments and depends on the ratio of the active motors. The model revealed that the ratio of active motors of more than 80% is required for sustainable motility. This insight would be useful in choosing appropriate materials for devices integrated with motor proteins.