Erythema nodosum and erythema induratum (nodular vasculitis): diagnosis and management
Erythema nodosum and erythema induratum (nodular vasculitis): diagnosis and management
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DOI：
10.1111/j.1529-8019.2010.01332.x
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发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
Patterson, James W.
中科院分区：
文献类型：
--
作者：
Gilchrist, Heidi;Patterson, James W.
结节性红斑是脂膜炎最常见的类型，它可能是由于各种潜在的感染或抗原刺激。其发病机制仍有待阐明，但嗜酸性炎症和肉芽肿性炎症都有牵连。除了治疗潜在的诱因，治疗选择主要包括非甾体抗炎药，对症治疗，碘化钾和秋水仙碱。硬化性红斑（结节性血管炎）是一种相关但明显不同的皮下脂肪临床病理反应模式。它通常是由结核分枝杆菌的抗原刺激引起的，但也可能与其他几种潜在的疾病有关。在结核病例中进行适当的抗菌治疗后，硬结性红斑的治疗方法与结节性红斑相似。
Erythema nodosum is the most common type of panniculitis; it may be due to a variety of underlying infectious or otherwise antigenic stimuli. The pathogenesis remains to be elucidated, but both neutrophilic inflammation and granulomatous inflammation are implicated. Beyond treating underlying triggers, therapeutic options consist mainly of nonsteroidal anti-inflammatory drugs, symptomatic care, potassium iodide, and colchicine. Erythema induratum (nodular vasculitis) is a related but distinctly different clinicopathologic reaction pattern of the subcutaneous fat. It is classically caused by an antigenic stimulus from Mycobacterium tuberculosis but may be associated with several other underlying disorders. After appropriate antimicrobial treatment in tuberculous cases, therapy for erythema induratum is similar to options for erythema nodosum.