P2Y2 receptors induced cell surface redistribution of αV integrin is required for activation of ERK 1/2 in U937 cells
P2Y2 receptors induced cell surface redistribution of αV integrin is required for activation of ERK 1/2 in U937 cells
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DOI：
10.1002/jcp.20946
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发表时间：
2007-05-01
影响因子：
5.6
通讯作者：
Gonzalez, Fernando A.
中科院分区：
文献类型：
--
作者：
Chorna, Nataliya E.;Chevres, Migdalia;Gonzalez, Fernando A.
Nucleotides released from cells due to stress, injury or inflammation, induce mitogenic effects in monocytes via activation of P2Y(2) nucleotide receptors (P2Y(2)Rs). Here we show that P2Y(2) nucleotide receptors in U937 monocytic cells regulate the activation of extracellular signal-regulated kinases 1 and 2 (ERK 1/2) by inducing the clustering of a, integrins. The activation of phosphatidylinositol 3-kinase by P2Y(2)R ligands was required for alpha(v) clustering, suggesting a means whereby two different classes of receptors communicate to induce mitogenic responses in monocytic cells. P2Y(2)R-induced alpha(v), clustering was also associated with a flattened phenotype of the U937 cells, consistent with the role of the P2Y(2)R in regulating early events in cell migration.
