Lipid mediators of insulin resistance
Lipid mediators of insulin resistance
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DOI：
10.1301/nr.2007.jun.s39-s46
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发表时间：
2007-06-01
影响因子：
6.1
通讯作者：
Summers, Scott A.
中科院分区：
文献类型：
--
作者：
Holland, William L.;Knotts, Trina A.;Summers, Scott A.
脂质异常如肥胖、循环游离脂肪酸水平升高和肌细胞内脂质过度积聚通常与胰岛素抵抗相关。这些观察结果促使研究人员推测，脂质在不适合脂肪储存的组织中的积累（例如，骨骼肌和肝脏）是胰岛素抵抗和代谢综合征的潜在成分。我们回顾了脂质在胰岛素反应组织中的代谢命运，并讨论了特定脂质代谢物（例如，神经酰胺、GM3神经节苷脂和二酰基甘油）作为胰岛素信号传导和作用的拮抗剂。
Lipid abnormalities such as obesity, increased circulating free fatty acid levels, and excess intramyocellular lipid accumulation are frequently associated with insulin resistance. These observations have prompted investigators to speculate that the accumulation of lipids in tissues not suited for fat storage (e.g., skeletal muscle and liver) is an underlying component of insulin resistance and the metabolic syndrome. We review the metabolic fates of lipids in insulin-responsive tissues and discuss the roles of specific lipid metabolites (e.g., ceramides, GM3 ganglioside, and diacylglycerol) as antagonists of insulin signaling and action.