Ocular vestibular-evoked myogenic potentials (oVEMPs) require extraocular muscles but not facial or cochlear nerve activity
Ocular vestibular-evoked myogenic potentials (oVEMPs) require extraocular muscles but not facial or cochlear nerve activity
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DOI：
10.1016/j.clinph.2008.12.030
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发表时间：
2009-03-01
影响因子：
4.7
通讯作者：
Murofushi, Toshihisa
中科院分区：
文献类型：
--
作者：
Chihara, Yasuhiro;Iwasaki, Shinichi;Murofushi, Toshihisa
目的：已发现颈部前庭诱发肌源电位（cVEMP）可用于前庭功能的临床测试。最近。研究人员表明，可以在眼外肌（oVEMP）周围记录短延迟、最初为负的表面肌电电位，以响应空气传导声音（ACS）、骨传导振动（BCV）和头部敲击。尽管这些位于眼睛周围的诱发电位很可能主要源自耳石-眼通路。不能完全消除其他神经活动污染的可能性。本研究的目的是通过使用临床发现检查这些可能性来澄清 oVEMP 的起源。方法：纳入 12 名健康受试者和 15 名患者。 15名患者中，3名患者接受了单侧眼眶内容物摘除术，1名患者接受了保留眼外肌的右眼球摘除术，5名患者患有面瘫，6名患者患有严重听力损失。这些受试者使用了 ACS 和/或 BCV。 结果：单侧眶内内容物的切除导致受影响一侧缺乏肌源性电位。另一方面，摘除眼球并保留眼外肌对反应没有重大影响。健康受试者与面瘫或重度听力损失患者之间的波形没有显着差异。结论：结果表明，眼睛下方记录的短潜伏期、最初为负诱发电位不受耳蜗或面神经活动的影响，并且依赖于眼外肌的存在。意义：本研究提供了 oVEMP 源自通过前庭眼通路激活的眼外肌的证据。 (C) 2008 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: Cervical vestibular evoked myogenic potentials (cVEMPs) have been found to be useful for clinical testing of vestibular function. Recently. investigators showed that short-latency, initially negative surface EMG potentials can be recorded around the extraocular Muscles (oVEMPs) in response to air-conducted sound (ACS), bone-conducted vibration (BCV),and head taps. Although these evoked potentials, which are located around the eyes, most likely originate primarily from the otolith-ocular pathway. the possibility of contamination by other nerve activities cannot be completely eliminated. The purpose of the present study was to clarify the origin of oVEMPs by examining these Possibilities using clinical findings.Methods: Twelve healthy subjects and 15 patients were enrolled. Of the 15 patients, 3 patients had undergone exenteration of the unilateral intraorbital contents, one had undergone exenteration of the right eye-ball with preservation of extraocular muscles, 5 had facial palsy, and 6 had profound hearing loss. ACS and/or BCV were used in these subjects.Results: Exenteration of the Unilateral intraorbital contents resulted in absence of myogenic potentials on the affected side. On the other hand, exenteration of the eyeball with preservation of extraocular muscles did not have a major impact on the responses. There were no significant differences in the waveforms between healthy subjects and patients with facial palsy or profound hearing loss.Conclusions: The results suggested that short-latency, initially negative evoked potentials recorded below the eyes are not affected by cochlear or facial nerve activities and are dependent on the presence of extraocular muscles. Significance: This study Provides the evidence that oVEMPs originate from extraocular muscles activated through the vestibulo-ocular pathway. (C) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.