Quantitative Digitography Measures Motor Symptoms and Disease Progression in Parkinson's Disease.
Quantitative Digitography Measures Motor Symptoms and Disease Progression in Parkinson's Disease.
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DOI：
10.3233/jpd-223264
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发表时间：
2022
影响因子：
5.2
通讯作者：
Bronte-Stewart, Helen
中科院分区：
文献类型：
--
作者：
Wilkins, Kevin B.;Petrucci, Matthew N.;Kehnemouyi, Yasmine;Velisar, Anca;Han, Katie;Orthlieb, Gerrit;Trager, Megan H.;O'Day, Johanna J.;Aditham, Sudeep;Bronte-Stewart, Helen
关键词：
帕金森病（PD）运动体征的评估需要亲自检查。然而，50%的PD患者无法获得神经科医生的帮助。可穿戴传感器可以提供一些电机信号的远程测量，但需要连续监测几天。一个主要的未满足的需求是所有主要运动体征的可靠指标，包括刚性，从一个简单的短主动任务，可以远程或在诊所执行。研究在便携式定量数字化成像（QDG）设备上重复交替手指敲击（RAFT）30秒（测量振幅和时间）是否能产生PD患者所有主要运动体征的可靠指标。96名PD患者和42名健康对照者进行了第32次QDG-RAFT任务和临床运动评估。对18名受试者进行了纵向随访，平均重复评估3年，最长6年。QDG-RAFT指标显示了PD和对照组之间的差异，并提供了完全运动障碍（MDS-RAFT RS III）和僵硬、运动迟缓、震颤、步态障碍和步态冻结（FOG）的相关指标。此外，QDG-RAFT跟踪了几年的疾病进展，并显示了运动僵硬和震颤显性表型之间的差异，以及有和没有FOG的人。QDG是一种可靠的技术，可用于临床或远程。这可以改善获得护理的机会，允许基于真实的时间接收的数据进行复杂的远程疾病管理，并准确监测PD中随时间推移的疾病进展。QDG-RAFT还提供治疗试验所需的全面运动指标。
Assessment of motor signs in Parkinson’s disease (PD) requires an in-person examination. However, 50% of people with PD do not have access to a neurologist. Wearable sensors can provide remote measures of some motor signs but require continuous monitoring for several days. A major unmet need is reliable metrics of all cardinal motor signs, including rigidity, from a simple short active task that can be performed remotely or in the clinic. Investigate whether thirty seconds of repetitive alternating finger tapping (RAFT) on a portable quantitative digitography (QDG) device, which measures amplitude and timing, produces reliable metrics of all cardinal motor signs in PD. Ninety-six individuals with PD and forty-two healthy controls performed a thirty-second QDG-RAFT task and clinical motor assessment. Eighteen individuals were followed longitudinally with repeated assessments for an average of three years and up to six years. QDG-RAFT metrics showed differences between PD and controls and provided correlated metrics for total motor disability (MDS-UPDRS III) and for rigidity, bradykinesia, tremor, gait impairment, and freezing of gait (FOG). Additionally, QDG-RAFT tracked disease progression over several years off therapy and showed differences between akinetic-rigid and tremor-dominant phenotypes, as well as people with and without FOG. QDG is a reliable technology, which could be used in the clinic or remotely. This could improve access to care, allow complex remote disease management based on data received in real time, and accurate monitoring of disease progression over time in PD. QDG-RAFT also provides the comprehensive motor metrics needed for therapeutic trials.