Recent advances in the immunogenetics of idiopathic inflammatory myopathy.
Recent advances in the immunogenetics of idiopathic inflammatory myopathy.
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DOI：
10.1186/ar3327
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发表时间：
2011-05-26
影响因子：
4.9
通讯作者：
Cooper RG
中科院分区：
文献类型：
--
作者：
Chinoy H;Lamb JA;Ollier WE;Cooper RG
本文综述了特发性炎性肌病免疫遗传学的研究进展。成人和青少年发病IIM的遗传风险的很大一部分在于主要组织相容性复合体（MHC），和个体人类白细胞抗原等位基因和特定血清学亚型之间存在紧密的关系，这反过来又决定了临床疾病表型。MHC外的多个遗传区域越来越多地被鉴定为赋予IIM疾病易感性。我们仍然面临着研究一种血清学和临床异质性疾病的任务，这种疾病比类风湿性关节炎等疾病要罕见几个数量级。一项正在进行的国际协调的IIM全基因组关联研究可能会为IIM免疫遗传学提供进一步的见解。
This review summarizes the previous and current literature on the immunogenetics of idiopathic inflammatory myopathy (IIM) and updates the research progress that has been made over the past decade. A substantial part of the genetic risk for developing adult- and juvenile-onset IIM lies within the major histocompatibility complex (MHC), and a tight relationship exists between individual human leukocyte antigen alleles and specific serological subtypes, which in turn dictate clinical disease phenotypes. Multiple genetic regions outside of the MHC are increasingly being identified in conferring IIM disease susceptibility. We are still challenged with the task of studying a serologically and clinically heterogeneous disorder that is rarer by orders of magnitude than the likes of rheumatoid arthritis. An ongoing and internationally coordinated IIM genome-wide association study may provide further insights into IIM immunogenetics.
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影响因子：
5.5
作者：
Chinoy, H.;Salway, F.;Cooper, R. G.
通讯作者：
Cooper, R. G.
影响因子：
4.9
作者：
Chinoy, H;Salway, F;Cooper, RG
通讯作者：
Cooper, RG
影响因子：
--
作者：
Mamyrova, Gulnara;O'Hanlon, Terrance P.;Rider, Lisa G.
通讯作者：
Rider, Lisa G.
影响因子：
9.8
作者：
Cullen, M;Perfetto, SP;Carrington, M
通讯作者：
Carrington, M
影响因子：
5.5
作者：
Chinoy, H.;Salway, F.;Cooper, R. G.
通讯作者：
Cooper, R. G.