SUBFORNICAL ORGAN LESIONS REDUCE THE PRESSOR EFFECT OF SYSTEMIC ANGIOTENSIN-II
SUBFORNICAL ORGAN LESIONS REDUCE THE PRESSOR EFFECT OF SYSTEMIC ANGIOTENSIN-II
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DOI：
10.1159/000123107
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发表时间：
1980-01-01
影响因子：
4.1
通讯作者：
SIMPSON, JB
中科院分区：
文献类型：
--
作者：
MANGIAPANE, ML;SIMPSON, JB
本文比较了电解损毁大鼠穹窿下器（SFO）前后静脉注射血管紧张素Ⅱ（AII）的升压作用。腹主动脉和静脉腔静脉导管分别用于测量动脉压和输注溶液。AII的升压作用在完全SFO病变后显著降低，但不受部分SFO病变或邻近组织对照病变的影响。静脉内输注α-肾上腺素能激动剂苯肾上腺素不受这些病变的影响。在协议的实验表明，SFO注射AII增加动脉压，目前的结果表明，一个显着的部分循环AII的升压作用是中枢介导的，SFO参与这种调解。
The pressor effect of i.v. angiotensin II (AII) was compared in the unrestrained rat before and after electrolytic lesions of the subfornical organ (SFO), the circumventricular organ of the dorsal third cerebral ventricle. Abdominal aortic and venal caval catheters were used to measure arterial pressure and to infuse solutions, respectively. The pressor effect of AII was significantly reduced following complete SFO lesions, but was unaffected by partial SFO lesions or by control lesions in adjacent tissue. The pressor effect of i.v. infusion of the .alpha.-adrenergic agonist, phenylephrine, was unaffected by any of these lesions. In agreement with experiments demonstrating that SFO injection of AII increases arterial pressure, the present results suggest that a significant portion of the pressor action of circulating AII is centrally mediated, and that the SFO participates in this mediation.