Analysis of a model for pH-sensitive hydrogels
Analysis of a model for pH-sensitive hydrogels
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DOI：
10.1016/j.polymer.2011.11.054
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发表时间：
2012-01-24
期刊：
影响因子：
4.6
通讯作者：
Mujumdar, Arun S.
中科院分区：
文献类型：
--
作者：
Kurnia, Jundika C.;Birgersson, Erik;Mujumdar, Arun S.
一个数学模型，包括守恒的质量，动量，和离子的水凝胶溶液pH值的变化推导，分析，验证和介绍。模型预测和实验结果吻合较好。为了获得对pH敏感性水凝胶的变形行为的物理洞察，对关键物理和操作参数进行了缩放分析和参数研究。结果表明，初始固定电荷密度、溶液离子强度、泊松比和杨氏模量在决定水凝胶溶胀度方面具有重要意义。此外，它是注意到，酸解离常数和温度的变化导致平衡溶胀曲线的显着移动。水凝胶的渗透性和尺寸被发现显著影响变形动力学：具有较高渗透性和/或较小尺寸的水凝胶表现出更快的变形。这些发现和特征尺度可以为设计利用pH敏感水凝胶的系统提供重要指导。(C)2011爱思唯尔有限公司保留所有权利。
A mathematical model comprising conservation of mass, momentum, and ions for a hydrogel subject to alterations of the solution pH is derived, analyzed, validated and presented. Good agreement between model predictions and their experimental counterpart are achieved. To gain a physical insight into the deformation behavior of the pH-sensitive hydrogel, a scaling analysis coupled with a parametric study is carried out for key physical and operational parameters. The results suggest the significance of initial fixed-charge density, solution ionic strength, Poisson ratio and Young modulus in determining swelling degree of the hydrogel. In addition, it is noted that changes in acid dissociation constant and temperature lead to a notable shift in equilibrium swelling curves. Permeability and size of the hydrogel were found to significantly affect the deformation kinetics: A hydrogel with higher permeability and/or smaller size exhibits faster deformation. These findings and the characteristic scales could provide important guidelines in designing systems utilizing pH-sensitive hydrogels. (C) 2011 Elsevier Ltd. All rights reserved.