Delivery of drugs and macromolecules to the mitochondria for cancer therapy
Delivery of drugs and macromolecules to the mitochondria for cancer therapy
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DOI：
10.1016/j.jconrel.2015.10.023
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发表时间：
2016-10-28
影响因子：
10.8
通讯作者：
Lim, Carol S.
中科院分区：
文献类型：
--
作者：
Lu, Phong;Bruno, Benjamin J.;Lim, Carol S.
线粒体是细胞器，在产生生命所必需的能量和执行细胞死亡途径方面具有关键功能。将药物和大分子靶向线粒体可以为癌症治疗提供诱导细胞死亡的有效手段，并且在过去十年中一直在积极追求。这篇综述将提供线粒体结构和功能的简要概述，它如何与癌症相关，重要的是，将讨论线粒体递送的不同策略，包括使用小分子，肽，编码蛋白质和MTS的基因的递送，以及将有效载荷靶向聚合物/纳米颗粒递送到线粒体。将讨论每种策略的优点和缺点。将评估使用最新线粒体靶向策略的具体实例，以及特定线粒体区室定位的潜在机会，这可能导致线粒体治疗的改进。未来的前景在线粒体靶向药物和大分子将被讨论。目前，这是一个未开发的领域，是癌症治疗新发现的主要领域。(C)2015爱思唯尔B. V.保留所有权利。
Mitochondria are organelles that have pivotal functions in producing the energy necessary for life and executing the cell death pathway. Targeting drugs and macromolecules to the mitochondria may provide an effective means of inducing cell death for cancer therapy, and has been actively pursued in the last decade. This review will provide a brief overview of mitochondrial structure and function, how it relates to cancer, and importantly, will discuss different strategies of mitochondrial delivery including delivery using small molecules, peptides, genes encoding proteins and MTSs, and targeting polymers/nanoparticles with payloads to the mitochondria. The advantages and disadvantages for each strategy will be discussed. Specific examples using the latest strategies for mitochondrial targeting will be evaluated, as well as potential opportunities for specific mitochondrial compartment localization, which may lead to improvements in mitochondrial therapeutics. Future perspectives in mitochondrial targeting of drugs and macromolecules will be discussed. Currently this is an under-explored area that is prime for new discoveries in cancer therapeutics. (C) 2015 Elsevier B.V. All rights reserved.