Depressive symptoms in hip fracture patients are associated with reduced monocyte superoxide production
Depressive symptoms in hip fracture patients are associated with reduced monocyte superoxide production
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DOI：
10.1016/j.exger.2014.01.028
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发表时间：
2014-06-01
影响因子：
3.9
通讯作者：
Lord, Janet M.
中科院分区：
文献类型：
--
作者：
Duggal, Niharika Arora;Beswetherick, Amy;Lord, Janet M.
衰老伴随着免疫系统功能的降低，称为免疫衰老，这与感染和死亡的风险增加有关。然而，免疫系统并不是孤立运作的，它可以被许多环境因素所改变，包括压力。在这项研究中，我们确定了身体压力（髋骨骨折）和心理压力（抑郁症状）是否对老年免疫系统，特别是单核细胞数量和功能有累加效应。我们评估了101名髋部骨折患者（81名女性）受伤后6周和6个月的免疫功能，以及43名健康年龄匹配的对照组（28名女性）。髋部骨折组中有38人在6周取样时被发现抑郁。髋部骨折患者外周血单核细胞计数、单核细胞亚群分布及TNF α分泌与健康对照组无明显差异。然而，我们观察到显着减少超氧化物的生产响应大肠杆菌在单核细胞的髋部骨折患者谁开发的抑郁症状相比，非抑郁髋部骨折患者（p = 0.002）或健康对照组（p = 0.008）6周后，骨折后6个月仍然下降。在以前的研究中，我们已经显示了抑郁症对髋部骨折患者中性粒细胞超氧化物生成的影响，这表明免疫细胞功能的这一方面对心理压力特别敏感。2014作者爱思唯尔公司出版
Ageing is accompanied by reduced functioning of the immune system, termed immunesenescence which is associated with increased risk of infection and mortality. However the immune system does not operate in isolation and can bemodified bymany environmental factors, including stress. In this studywe determinedwhether physical stress (hip fracture) and psychological distress (depressive symptoms) had additive effects upon the aged immune system, specifically on monocyte numbers and function. We assessed immune function in 101 hip fracture patients (81 female) 6 weeks and 6 months after injury and 43 healthy age matched controls (28 females). Thirty-eight of the hip fracture group were found to be depressed at the 6 week sampling. No differences in peripheralmonocyte count, distribution ofmonocyte subsets or TNFa secretion were observed between hip fracture patients and healthy controls. However we observed significantly reduced superoxide production in response to Escherichia coli in the monocytes of hip fracture patients who developed depressive symptoms compared with non-depressed hip fracture patients (p = 0.002) or healthy controls (p = 0.008) 6 weeks after the fracture which remained decreased 6 months following injury. In previous studies we have shown an effect of depression on neutrophil superoxide generation in hip fracture patients, suggesting a particular susceptibility of this aspect of immune cell function to psychological stress. c 2014 The Authors. Published by Elsevier Inc.