Microstructural white matter changes in primary torsion dystonia
Microstructural white matter changes in primary torsion dystonia
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DOI：
10.1002/mds.21806
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发表时间：
2008-01-30
影响因子：
8.6
通讯作者：
Eidelberg, David
中科院分区：
文献类型：
--
作者：
Carbon, Maren;Kingsley, Peter B.;Eidelberg, David
原发性扭转肌张力障碍（PTD）被认为是基底神经节的一种疾病。然而，最近的数据表明，一种广泛的病理涉及运动控制通路。在本报告中，我们探讨了PTD是否与运动控制通路中的异常解剖连接有关。应用扩散张量磁共振成像（DT-MRI）对脑白质微结构进行评价。我们发现，PTD患者左小脑上脚附近的桥脑干和双侧感觉运动区白质的分数各向异性（轴突完整性和连贯性的衡量指标）显著降低。因此，我们的数据支持小脑-丘脑-皮质通路紊乱作为PTD临床表现的一个原因的可能性。(C) 2007运动障碍学会。
Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT-MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the Pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD. (C) 2007 Movement Disorder Society.