Airway metabolome and chronic lung disease of prematurity.
Airway metabolome and chronic lung disease of prematurity.
复制标题
气道代谢组和早产儿慢性肺病。
DOI：
10.1016/j.jpeds.2014.09.050
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Aschner,JudyL
中科院分区：
文献类型：
--
作者：
Rastogi,Deepa;Aschner,JudyL
Bronchopulmonary dysplasia (BPD) is the most common pulmonary sequela of prematurity, affecting about 30% of all very low birth weight premature infants. 1, 2 Although pulmonary morbidity decreases in the majority of children with BPD with somatic and, presumably, lung growth in the first 2 years of life, there is a subset of children who persist with respiratory symptoms into their childhood and adolescent years. 3 Persistence of pulmonary disease in childhood, referred to as chronic lung disease of prematurity, is often associated with failure to thrive, school absences attributable to frequent exacerbations, and poor quality of life. 4, 5Pulmonary exacerbations in former preterm infants with chronic lung disease present with wheezing, thereby mimicking asthma. 6 However, the disease development and pathophysiology of chronic lung disease of prematurity is inherently different from asthma. 6 Although bronchial hyper-reactivity and lower airway obstruction in asthma are due to airway inflammation, most frequently associated with atopy, 7 chronic lung disease of prematurity is characterized by altered development of the airways with areas of smooth muscle hyperplasia, vascular rarefaction, and decreased alveolarization. 8 Improved understanding of the pathophysiology of lung injury in preterm infants has led to new therapeutics and improved respiratory and nutritional management during the neonatal intensive care unit hospitalization and the first 2 years of life. 5, 6 However, there is a dearth of information on the pathophysiology of chronic lung disease of prematurity among older children with and without a diagnosis of asthma. Moreover, there are no currently available practical tools to differentiate lower airway disease that underlies chronic lung disease of prematurity vs asthma.
