Longitudinal trajectories of hippocampal and prefrontal contributions to episodic retrieval: Effects of age and puberty.
Longitudinal trajectories of hippocampal and prefrontal contributions to episodic retrieval: Effects of age and puberty.
复制标题
海马和前额叶对情景检索的贡献的纵向轨迹：年龄和青春期的影响。
DOI：
10.1016/j.dcn.2018.10.003
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发表时间：
2019
影响因子：
4.7
通讯作者：
Ghetti,Simona
中科院分区：
文献类型：
--
作者：
Selmeczy,Diana;Fandakova,Yana;Grimm,KevinJ;Bunge,SilviaA;Ghetti,Simona
本研究探讨了海马和前额叶的纵向变化对情景提取的贡献。在8至14岁儿童的项目-背景关联记忆任务期间收集功能性神经成像数据，其中个体在0.75-3.7年的过程中扫描1-3次（时间点1 N = 90;时间点2 N = 83，时间点3 N = 75）。我们研究了与情景提取相关的功能激活的发展变化（正确的项目背景>不正确的项目背景对比），并询问青春期的变化是否有助于激活模式的发展变化。观察到非线性发展轨迹。在海马体中，激活在儿童时期随着年龄的增长而减少，然后增加到青春期早期。在背外侧前额叶皮层，激活最初基本上是不存在的，但随着时间的推移迅速加速。独立于年龄，青春期状态的变化还预测了最初较大的儿童的项目背景激活的增加，以及两个地区和两个青春期指标的最初较小的儿童的减少：青春期发育量表和唾液睾酮。这些研究结果表明，年龄和青春期状态的变化，独特的记忆相关的激活，青春期发作的时间可能在支持记忆检索的神经机制中发挥重要作用。
The current study investigated longitudinal change in hippocampal and prefrontal contribution to episodic retrieval. Functional neuroimaging data were collected during an item-context association memory task for children between the ages of 8 and 14 with individuals scanned 1–3 times over the course of 0.75–3.7 years (Timepoint 1 N = 90; Timepoint 2 N = 83, Timepoint 3 N = 75). We investigated developmental changes in functional activation associated with episodic retrieval (correct item-context > incorrect item-context contrast) and asked whether pubertal changes contributed to developmental changes in pattern of activation. Non-linear developmental trajectories were observed. In the hippocampus, activation decreased with age during childhood and then increased into early adolescence. In the dorsolateral prefrontal cortex, activation was largely absent initially, but quickly accelerated over time. Independent of age, changes in pubertal status additionally predicted increases in item-context activation in initially older children, and decreases in initially younger children across both regions and two indicators of puberty: the Pubertal Development Scale and salivary testosterone. These findings suggest that changes in both age and pubertal status uniquely contribute to memory-related activation, and the timing of pubertal onset may play an important role in the neural mechanisms supporting memory retrieval.