Content-specific source encoding in the human medial temporal lobe
Content-specific source encoding in the human medial temporal lobe
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DOI：
10.1037/0278-7393.34.4.769
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发表时间：
2008-07-01
影响因子：
2.6
通讯作者：
Davachi, L.
中科院分区：
文献类型：
--
作者：
Awipi, T.;Davachi, L.
尽管已知内侧颞叶 (MTL) 对于情景编码至关重要，但各个 MTL 亚区域的贡献仍不清楚。来自识别记忆研究的数据提供的证据表明，海马体支持对后来的情景记忆很重要的关系编码，而鼻周皮层则与支持后来的项目熟悉程度的编码相关。然而，现有数据也强烈暗示鼻周皮层参与物体处理和编码，这表明鼻周过程可能有助于后来对物体源细节的情景回忆。为了研究这种可能性，在参与者处理与 6 个重复对象中的 1 个配对的新场景时，根据随后的记忆结果分析了 MTL 子区域的编码激活。具体来说，与后来成功的场景识别记忆相关的编码激活是根据编码期间与场景配对的对象的源记忆的激活来评估的。与报告鼻周皮层和物品熟悉度之间的联系的研究相反，我们发现右侧鼻周皮层的编码激活与配对物体的成功回忆相关。此外，其他 MTL 子区域也表现出内容特定的激活源编码模式，表明 MTL 随后的记忆效应对刺激类别敏感。
Although the medial temporal lobe (MTL) is known to be essential for episodic encoding, the contributions of individual MTL subregions remain unclear. Data from recognition memory studies have provided evidence that the hippocampus supports relational encoding important for later episodic recollection, whereas the perirhinal cortex has been linked with encoding that supports later item familiarity. However, extant data also strongly implicate the perirhinal cortex in object processing and encoding, suggesting that perirhinal processes may contribute to later episodic recollection of object source details. To investigate this possibility, encoding activation in MTL subregions was analyzed on the basis of subsequent memory outcome while participants processed novel scenes paired with 1 of 6 repeating objects. Specifically, encoding activation correlating with later successful scene recognition memory was evaluated against that of source recollection for the object paired with the scene during encoding. In contrast to studies reporting a link between perirhinal cortex and item familiarity, it was found that encoding activation in the right perirhinal cortex correlates with successful recollection of the paired object. Furthermore, other MTL subregions also exhibited content-specific source encoding patterns of activation, suggesting that MTL subsequent memory effects are sensitive to stimulus category.