Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
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DOI：
10.1023/a:1008983615045
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发表时间：
2000-04-01
影响因子：
3
通讯作者：
Van der Ploeg, LHT
中科院分区：
文献类型：
--
作者：
Chen, AS;Metzger, JM;Van der Ploeg, LHT
我们评估了黑皮质素-4受体（MC-4 R）在小鼠代谢率和食物摄入控制中的作用。非选择性MC-R激动剂melanotan II（MT-II;一种环状七肽）的腹膜内给药增加了野生型小鼠的代谢率，而MC-4 R敲除小鼠对MT-II对代谢率的影响不敏感。MC-4 R基因敲除小鼠也对MT-II减少食物摄入的作用不敏感。我们得出结论，MC-4 R可以介导控制代谢率和食物摄入量的小鼠。我们推断MC-3R在介导MT-II对野生型小鼠基础代谢率和食物摄入的急性影响中的作用似乎是有限的。
We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.