Critical signal transduction pathways in CLL.
Critical signal transduction pathways in CLL.
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DOI：
10.1007/978-1-4614-8051-8_10
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发表时间：
2013
影响因子：
--
通讯作者：
Kay, Neil E.
中科院分区：
文献类型：
--
作者：
Ghosh, Asish K.;Kay, Neil E.
Receptor tyrosine kinases (RTKs) are cell-surface transmembrane receptors that contain regulated kinase activity within their cytoplasmic domain and play a critical role in signal transduction in both normal and malignant cells. Besides B-cell receptor (BCR) signaling in CLL, multiple RTKs have been reported to be constitutively active in CLL B-cells resulting in enhanced survival and resistance to apoptosis of the leukemic cells induced by chemotherapeutic agents. In addition to increased plasma levels of various types of cytokines/growth factors in CLL, we and others have detected that CLL B-cells spontaneously produce multiple cytokines in vitro which may constitute an autocrine loop of RTK activation on the leukemic B-cells. Moreover, aberrant expression and activation of non-RTKs, for example Src/Syk kinases, induce resistance of the leukemic B-cells to therapy. Based on current available knowledge, we detailed the impact of aberrant activities of various RTKs/non-RTKs on CLL B-cell survival and the potential of using these signaling components as future therapeutic targets in CLL therapy.
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DOI：
10.1158/1078-0432.ccr-10-2879
发表时间：
2011-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Amrein PC;Attar EC;Takvorian T;Hochberg EP;Ballen KK;Leahy KM;Fisher DC;Lacasce AS;Jacobsen ED;Armand P;Hasserjian RP;Werner L;Neuberg D;Brown JR
通讯作者：
Brown JR
影响因子：
2.7
作者：
Aguayo, A;Manshouri, T;Albitar, M
通讯作者：
Albitar, M
影响因子：
30.8
作者：
Afzal, AR;Rajab, A;Jeffery, S
通讯作者：
Jeffery, S
影响因子：
11
作者：
Chan, PC;Chen, SY;Chen, HC
通讯作者：
Chen, HC
影响因子：
4.8
作者：
BEITNERJOHNSON, D;LEROITH, D
通讯作者：
LEROITH, D