Immune modulation by MANF promotes tissue repair and regenerative success in the retina.
Immune modulation by MANF promotes tissue repair and regenerative success in the retina.
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MANF免疫调节可促进视网膜的组织修复和再生成功。
DOI：
10.1126/science.aaf3646
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发表时间：
2016-07-01
期刊：
影响因子：
--
通讯作者：
Lamba DA
中科院分区：
文献类型：
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作者：
Neves J;Zhu J;Sousa-Victor P;Konjikusic M;Riley R;Chew S;Qi Y;Jasper H;Lamba DA
再生疗法受到老化和患病组织中不利环境的限制。提高成功率的一个有希望的策略是平衡炎症和抗炎信号并增强内源性组织修复机制。在这里，我们确定了一种保守的免疫调节机制，该机制控制受损视网膜细胞和免疫细胞之间的相互作用，以促进组织修复。在果蝇和小鼠受损的视网膜中，血小板源性生长因子（PDGF）样信号诱导先天免疫细胞中的中脑星形胶质细胞源性神经营养因子（MANF）。MANF促进了先天免疫细胞的替代激活，增强了神经保护和组织修复，并提高了感光细胞替代疗法的成功率。因此，在组织修复和再生期间需要免疫调节。这种方法可以提高基于干细胞的再生疗法的功效。
Regenerative therapies are limited by unfavorable environments in aging and diseased tissues. A promising strategy to improve success is to balance inflammatory and anti-inflammatory signals and enhance endogenous tissue repair mechanisms. Here, we identified a conserved immune modulatory mechanism that governs the interaction between damaged retinal cells and immune cells to promote tissue repair. In damaged retina of flies and mice, Platelet-Derived Growth Factor (PDGF)-like signaling induced Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) in innate immune cells. MANF promoted alternative activation of innate immune cells, enhanced neuroprotection and tissue repair, and improved the success of photoreceptor replacement therapies. Thus, immune modulation is required during tissue repair and regeneration. This approach may improve the efficacy of stem-cell based regenerative therapies.