Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators
Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators
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DOI：
10.1016/j.bmcl.2009.11.100
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发表时间：
2010-01-15
影响因子：
2.7
通讯作者：
Lindsley, Craig W.
中科院分区：
文献类型：
--
作者：
Yang, Feng V.;Shipe, William D.;Lindsley, Craig W.
采用迭代模拟文库合成方法，探索了喹诺酮羧酸系列选择性M-1正变构调节剂，并确定了提高效价和血浆游离分数的策略。(C)2009爱思唯尔有限公司。保留所有权利。
An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M-1 positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified. (C) 2009 Elsevier Ltd. All rights reserved.