Clinical characteristics of 10 patients with continuous spikes and waves during slow sleep syndrome
Clinical characteristics of 10 patients with continuous spikes and waves during slow sleep syndrome
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DOI：
10.1016/j.pediatrneurol.2008.02.007
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发表时间：
2008-06-01
影响因子：
3.8
通讯作者：
Kiris, Nurcihan
中科院分区：
文献类型：
--
作者：
Herguener, M. Oezlem;Incecik, Faruk;Kiris, Nurcihan
慢睡眠综合征期间的连续尖峰和波的特征在于在至少85%的非快速眼动睡眠中存在尖峰和波放电。相关的临床特征各不相同。在这里，这种综合征的10例患者的特点进行了比较，在文献中。患者年龄范围为4至11岁。所有患者主要为夜间部分运动性或全身强直阵挛性发作; 4例患者也有每日失张力性发作。10例患者均有不同程度的神经心理障碍：9例患者智商低（第10例诊断为注意缺陷多动障碍，智商正常）; 4例患者有自闭症样特征。除了智力迟钝（7/10），身体和神经系统的结果是正常的。两名患者检测到明显的锥体束征和小头畸形，另一名患者发现张力减退、共济失调和双侧锥体束征。6例患者的头颅磁共振成像结果正常，其他4例患者有一些异常结果。慢睡眠综合征是一种罕见的儿童癫痫综合征。在慢睡眠综合征患者中发现了各种临床和神经认知特征，这些患者在慢睡眠综合征期间具有连续的棘波和波。(c)2008年，Elsevier Inc. All rights reserved.
Continuous spikes and waves during slow sleep syndrome is characterized by the presence of spike-and-wave discharges in at least 85% of non-rapid eye movement sleep. Associated clinical features vary. Here, features of 10 patients with this syndrome are compared to those in the literature. Patients ranged in age from 4 to 11 years. All patients had predominantly nocturnal partial motor or generalized tonic-clonic seizures; four patients also had daily atonic seizures. All 10 patients had different degrees of neuropsychologic disturbances: 9 patients had low intelligence quotient scores (the 10th, diagnosed attention deficit and hyperactivity disorder, had normal intelligence quotient score); 4 patients had autistic-like features. Apart from mental retardation (7 of 10), physical and neurologic findings were normal. Significant pyramidal signs and microcephaly were detected in two patients, and hypotonia, ataxia, and bilateral pyramidal signs were found in one other. Cranial magnetic resonance imaging findings were normal for 6 patients; the other 4 had some abnormal findings. Continuous spikes and waves during slow sleep syndrome is a rare epileptic syndrome in childhood. A variety of clinical and neurocognitive features were found in patients with continuous spikes and waves during slow sleep syndrome. (c) 2008 by Elsevier Inc. All rights reserved.