Cognitive Activity Is Associated with Cognitive Function over Time in a Diverse Group of Older Adults, Independent of Baseline Biomarkers.
Cognitive Activity Is Associated with Cognitive Function over Time in a Diverse Group of Older Adults, Independent of Baseline Biomarkers.
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在不同的老年人群体中，随着时间的推移，认知活动与认知功能相关，与基线生物标志物无关。
DOI：
10.1159/000531208
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发表时间：
2023
影响因子：
5.7
通讯作者：
Rajan,KumarB
中科院分区：
文献类型：
--
作者：
Krueger,KristinR;Desai,Pankaja;Beck,Todd;Wilson,RobertS;Evans,Denis;Rajan,KumarB
背景更频繁地参与认知活动与老年人更好的认知功能相关，但其作用机制尚不完全清楚。认知活动的增加是否对认知健康有有意义的益处，或者认知活动的减少是否代表认知障碍的前驱症状，仍然存在争议。神经生物标志物提供了一种在认知衰老背景下检查这种关系的新方法。方法我们在一项纵向、基于人群的研究中，检查了社区居住参与者的自我报告认知活动、认知功能和三种生物标志物浓度之间的关联。通过要求参与者对 7 种活动的频率进行评分来测量基线认知活动：(1) 看电视，(2) 听广播，(3) 参观博物馆，(4) 玩游戏，如纸牌、跳棋、填字游戏或其他拼图或游戏，(5) 读书，(6) 阅读杂志，(7) 阅读报纸。认知功能通过四项测试（简易精神状态检查、数字符号测试以及东波士顿测试的即时和延迟回忆）进行测量，平均为综合分数。在基线时，我们评估了总 tau (tau)、神经丝光 (NfL) 和神经胶质原纤维酸性蛋白 (GFAP) 的浓度。结果研究样本包括 1,168 名老年参与者，主要是非西班牙裔黑人 (60%) 和女性 (63%)。基线时，他们的平均年龄为 77 岁，受教育年限为 12.6 年。混合效应模型表明，认知活动与基线和随着时间的推移更好的认知功能相关。将每个生物标志物添加到模型后，这些关系仍然存在。在平均 6.4 年的随访中，认知活动与 tau 模型中的认知下降相关（估计值= 0.0123；p 值= 0.03），而在 NfL（估计值= 0.0110；p 值= 0.06）和 GFAP（估计值= 0.0111；p 值= 0.06）模型中轻度减弱。随着时间的推移，生物标志物不会改变认知活动和认知功能之间的关联。结论认知活动对认知的益处似乎与生物标志物无关：tau、NfL 和 GFAP（在基线时测量）。更频繁的认知活动可能有利于具有多种潜在疾病风险和表现的老年人的认知健康。
BackgroundMore frequent engagement in cognitive activity is associated with better cognitive function in older adults, but the mechanism of action is not fully understood. Debate remains whether increased cognitive activity provides a meaningful benefit for cognitive health or if decreased cognitive activity represents a prodrome of cognitive impairment. Neurological biomarkers provide a novel way to examine this relationship in the context of cognitive aging.MethodsWe examined the association of self-reported cognitive activity, cognitive function, and concentrations of three biomarkers in community-dwelling participants of a longitudinal, population-based study. Cognitive activity was measured at baseline by asking participants to rate the frequency of 7 activities:(1) viewing television,(2) listening to the radio,(3) visiting a museum,(4) playing games, such as cards, checkers, crosswords, or other puzzles or games,(5) reading books,(6) reading magazines, and (7) reading newspapers. Cognitive function was measured with a battery of four tests (Mini-Mental State Examination, Digit Symbol Test, and the immediate and delayed recall of the East Boston Test) averaged into a composite score. At baseline, we evaluated the concentration of total tau (tau), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP).ResultsThe study sample comprised 1,168 older participants, primarily non-Hispanic Blacks (60%) and women (63%). At baseline, they were an average of 77 years old with 12.6 years of education. Mixed-effects models showed that cognitive activity was associated with better cognitive functioning at baseline and over time. These relationships remained after each biomarker was added to the model. Over an average of 6.4 years of follow-up, cognitive activity was associated with cognitive decline in the model with tau (estimate= 0.0123; p value= 0.03) and was mildly attenuated in the models with NfL (estimate= 0.0110; p value= 0.06) and GFAP (estimate= 0.0111; p value= 0.06). Biomarkers did not modify the association between cognitive activity and cognitive function over time.ConclusionThe benefits of cognitive activity on cognition appear to be independent of biomarkers: tau, NfL, and GFAP, measured at baseline. More frequent cognitive activity may benefit the cognitive health of older adults with a wide range of potential disease risk and presentations.