Detection and follow-up of cardiovascular disease and risk factors in the Southern Cone of Latin America: the CESCAS I study
Detection and follow-up of cardiovascular disease and risk factors in the Southern Cone of Latin America: the CESCAS I study
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DOI：
10.1136/bmjopen-2011-000126
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发表时间：
2011-01-01
期刊：
影响因子：
2.9
通讯作者：
He, Jiang
中科院分区：
文献类型：
--
作者：
Luis Rubinstein, Adolfo;Edith Irazola, Vilma;He, Jiang
导读：心血管疾病在全世界呈上升趋势，每年造成1670万人死亡，其中80%发生在低收入和中等收入国家。在阿根廷、智利和乌拉圭，关于心血管危险因素的现有数据主要来自主要基于自我报告的横断面研究或使用方便小样本进行的研究。CESCAS一期研究将对该区域心血管疾病的流行和分布以及长期趋势及其危险因素作出可靠估计。方法和分析：CESCAS I是一项观察性前瞻性队列研究，采用多阶段概率样本，共有8000名年龄在35-74岁之间的参与者，来自代表拉丁美洲南锥体的四个中等城市：阿根廷的巴里洛切和马科斯帕兹，智利的特木科和乌拉圭的潘多-巴罗斯布兰科斯。在第一阶段，将分两个阶段收集关于接触危险因素和心血管疾病流行率的基线数据：(1)在家庭和(2)在保健中心。通过具体的问卷调查、身体测量、心电图和隔夜空腹血液样本来测量血脂、葡萄糖和肌酐水平，将收集病史、风险因素、生活方式和健康利用方面的信息。在第二阶段，将获得关于心血管疾病事件发生率以及暴露与事件之间关系的年度随访数据。伦理和传播：该议定书已获得阿根廷、智利、乌拉圭和美国机构审查委员会的正式伦理批准。由于缺乏后续研究，阿根廷、智利和乌拉圭无法在人口一级执行危险因素分层和管理战略。然而，CESCAS I的研究数据将有助于制定基于初级保健干预的公共卫生战略，从而有助于改善该地区的心血管健康。
Introduction: Cardiovascular diseases (CVD) are increasing throughout the world and cause 16.7 million deaths each year, 80% of which occur in low and middle income countries. In Argentina, Chile and Uruguay, the available data on cardiovascular risk factors come predominantly from cross-sectional studies that are principally based on self-report or studies conducted with small convenience samples. The CESCAS I study will generate reliable estimates of the prevalence and distribution of and secular trends in CVD and its risk factors in this region.Methods and analysis: CESCAS I is an observational prospective cohort study with a multistage probabilistic sample of 8000 participants aged 35-74 years from four mid-sized cities representing the Southern Cone of Latin America: Bariloche and Marcos Paz in Argentina, Temuco in Chile and Pando-Barros Blancos in Uruguay. In the first phase, baseline data regarding exposure to risk factors and prevalence of CVD will be collected in two stages: (1) in homes and (2) in health centres. Information will be gathered on medical history, risk factors, lifestyles and health utilisation through specific questionnaires, physical measurements, an ECG and an overnight, fasting blood sample to measure levels of serum lipids, glucose and creatinine. In the second phase, annual follow-up data will be obtained on the incidence rate of CVD events and the association between exposure and events.Ethics and dissemination: The protocol has obtained formal ethics approval from institutional review boards in Argentina, Chile, Uruguay and the USA. The lack of follow-up studies has prevented Argentina, Chile and Uruguay from implementing risk factor stratification and management strategies at a population level. However, the CESCAS I study data will help the development of public health strategies based on primary care intervention, thus helping to improve cardiovascular health in this region.