Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
复制标题
针对全身性红斑狼疮的自身抗原聚集在凋亡角质形成细胞上的两个表面结构中。
DOI：
10.1084/jem.179.4.1317
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发表时间：
1994-04-01
影响因子：
15.3
通讯作者：
Rosen, A
中科院分区：
文献类型：
--
作者：
Casciola-Rosen, L A;Anhalt, G;Rosen, A
系统性红斑狼疮是一种多系统自身免疫性疾病，其自身抗体反应针对不同亚细胞位置的多种自身抗原。我们在这里表明，这些自身抗原聚集在凋亡细胞表面的两个不同的水泡群体中。较小的水泡群包含碎裂的内质网(ER)和核糖体，以及核糖核蛋白Ro。较大的气泡(凋亡体)含有核小体DNA、Ro、La和小的核糖核蛋白。这些自身抗原簇的共同之处在于它们靠近内质网和核膜，这是凋亡细胞中活性氧物种生成增加的地方。这些部位的氧化修饰可能是将这组不同的分子作为自身抗原结合在一起的一种机制。
Systemic lupus erythematosus is a multisystem autoimmune disease in which the autoantibody response targets a variety of autoantigens of diverse subcellular location. We show here that these autoantigens are clustered in two distinct populations of blebs at the surface of apoptotic cells. The population of smaller blebs contains fragmented endoplasmic reticulum (ER) and ribosomes, as well as the ribonucleoprotein, Ro. The larger blebs (apoptotic bodies) contain nucleosomal DNA, Ro, La, and the small nuclear ribonucleoproteins. These autoantigen clusters have in common their proximity to the ER and nuclear membranes, sites of increased generation of reactive oxygen species in apoptotic cells. Oxidative modification at these sites may be a mechanism that unites this diverse group of molecules together as autoantigens.