The effect upon the human vaginal histology of the long-term use of the injectable contraceptive Depo-Provera
The effect upon the human vaginal histology of the long-term use of the injectable contraceptive Depo-Provera
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DOI：
10.1016/s0010-7824(00)00132-3
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发表时间：
2000-07-01
期刊：
影响因子：
2.9
通讯作者：
Faúndes, A
中科院分区：
文献类型：
--
作者：
Bahamondes, L;Trevisan, M;Faúndes, A
本研究的目的是评价长期使用长效注射避孕药醋酸甲羟孕酮（DMPA）对人阴道组织学的影响。将目前使用DMPA作为避孕方法2年和3年的20名绝经前妇女与20名定期避孕的妇女进行比较，这些妇女在研究前的最后6个月内从未使用Depo-Provera和/或其他类型的激素避孕药。受试者和对照组按年龄（+/-1岁）、体重指数（kg/m2）（+/-1.0）、怀孕次数（+/-1）、首次性交年龄（+/-1岁）、性活动年数（+/-1年）和一生中伴侣数量（+/-1）匹配。使用者在末次注射后90+/-7天进行阴道活检，非使用者在月经周期的第20-25天进行阴道活检。此外，在活检当天，采集血样以测量雌二醇（所有女性）和使用者的DMPA。血清雌二醇水平明显低于对照组（P < 0.001）。DMPA使用者的阴道上皮厚度不小于对照组，两组每mm上皮的朗格汉斯细胞平均计数几乎相同，阴道成熟指数无显著差异。总之，使用Depo-Provera 2 - 3年不会影响阴道上皮变薄、朗格汉斯细胞计数或成熟指数。(C)2000 Elsevier Science Inc. All rights reserved.
The objective of the study was to evaluate the effect of long-term use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) on human vaginal histology. Twenty premenopausal women currently using DMPA as a contraceptive method for two and three years were compared with 20 regularly menstruating women, who never used Depo-Provera and/or other kind of hormonal contraceptive in the last 6 months prior to the study. Subjects and controls were matched by age (+/-1 year), body mass index (kg/m(2)) (+/-1.0), number of pregnancies (+/-1), age at first intercourse (+/-1 year), years of sexual activity (+/-1 year), and number of partners during their life (+/-1). Vaginal biopSies were performed in users at 90+/-7 days:after the last injection and in nonusers at day 20-25 of the menstrual cycle. In addition, at the day of the biopsy a blood sample was collected to measure estradiol (in all women) and DMPA in users. The level of serum estradiol was significantl lower in Depo-Provera users than in controls (p < 0.001). The thickness of the vaginal epithelium was not smaller among DMPA users than among controls, the mean count of Langerhans cells per mm of epithelium were almost identical in both groups, and no significant differences were found on the vaginal maturation;indices. Tn conclusion, the use of Depo-Provera between two and three years did not affect vaginal thinning of the epithelium, Langerhans cell count or maturation index. (C) 2000 Elsevier Science Inc. All rights reserved.