Cardiovascular disease risk factors, tract-based structural connectomics, and cognition in older adults
Cardiovascular disease risk factors, tract-based structural connectomics, and cognition in older adults
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DOI：
10.1016/j.neuroimage.2019.04.024
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发表时间：
2019-08-01
期刊：
影响因子：
5.7
通讯作者：
Lamar, Melissa
中科院分区：
文献类型：
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作者：
Boots, Elizabeth A.;Zhan, Liang;Lamar, Melissa
心血管疾病危险因素（CVD-RF）与老年人灰质和白质完整性下降以及认知障碍有关。关于 CVD-RF、大脑结构连接体完整性和认知之间的相互作用，人们知之甚少。我们检查了 94 名非痴呆/非抑郁老年人的 CVD-RF 是否与基于束的结构连接测量相关，以及连接的改变是否介导 CVD-RF 和认知之间的关联。参与者（年龄 = 68.2 岁；52.1% 为女性；46.8% 为黑人）接受了 CVD-RF 评估、MRI 和认知评估。 Framingham 10 年中风风险 (FSRP-10) 量化了 CVD-RF。图论分析将 T1 衍生的灰质感兴趣区域（ROI；与 CVD-RF 和痴呆相关的 23 个先验 ROI）和扩散 MRI 衍生的白质纤维束成像整合到连接矩阵中，分析局部效率和节点强度。主成分分析得出反映执行功能的三个旋转因子得分（EF；FAS、线索测试（TMT）B-A、字母数字排序、矩阵推理）；注意力/信息处理（AIP；TMT-A、TMT-Motor、数字符号）；和记忆（CVLT-II 试验 1-5 总计、延迟自由回忆、识别辨别能力）。 FSRP-10 和连接组 ROI 之间的线性回归根据文字阅读、颅内容积和白质高信号进行调整，显示与八个 ROI 中的节点强度呈负相关（p 值）
Cardiovascular disease risk factors (CVD-RFs) are associated with decreased gray and white matter integrity and cognitive impairment in older adults. Less is known regarding the interplay between CVD-RFs, brain structural connectome integrity, and cognition. We examined whether CVD-RFs were associated with measures of tract-based structural connectivity in 94 non-demented/non-depressed older adults and if alterations in connectivity mediated associations between CVD-RFs and cognition. Participants (age = 68.2 years; 52.1% female; 46.8% Black) underwent CVD-RF assessment, MRI, and cognitive evaluation. Framingham 10-year stroke risk (FSRP-10) quantified CVD-RFs. Graph theory analysis integrated T1-derived gray matter regions of interest (ROIs; 23 a-priori ROIs associated with CVD-RFs and dementia), and diffusion MRI-derived white matter tractography into connectivity matrices analyzed for local efficiency and nodal strength. A principal component analysis resulted in three rotated factor scores reflecting executive function (EF; FAS, Trail Making Test (TMT) B-A, Letter-Number Sequencing, Matrix Reasoning); attention/information processing (AIP; TMT-A, TMT-Motor, Digit Symbol); and memory (CVLT-II Trials 1-5 Total, Delayed Free Recall, Recognition Discriminability). Linear regressions between FSRP-10 and connectome ROIs adjusting for word reading, intracranial volume, and white matter hyperintensities revealed negative associations with nodal strength in eight ROIs (p-values