The influencing factors and functions of DNA G-quadruplexes
The influencing factors and functions of DNA G-quadruplexes
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DNA G-四链体的影响因素及功能
DOI：
10.1002/cbf.3505
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Jiang-Feng Wu
中科院分区：
文献类型：
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作者：
Wen-Fang Yuan;Lin-Yan Wan;Hu Peng;Yuan-Mei Zhong;Wen-Li Cai;Yan-Qiong Zhang;Wen-Bing Ai;Jiang-Feng Wu
由于DNA或RNA中鸟嘌呤序列的串联重复，G-四链体形成折叠结构。它们采用多种构象，这取决于许多因素，包括环和阳离子的类型、核苷酸链数目和G-四链体的主链极性。同时，G-四链体的不同构象对其生物学功能也有一定的影响，如抑制转录、翻译和DNA复制等。此外，G-四链体结合蛋白也影响G-四链体的结构和功能。一些化学合成的G-四链体序列已被证明具有生物活性。例如，AS 1411的双分子G-四链体可作为外源性药物的靶点，抑制恶性肿瘤的增殖。G-四链体也用作递送纳米颗粒的载体。因此，确定影响G-四链体结构的因素，保持G-四链体的稳定性是非常重要的。本文主要讨论了影响G-四链体的因素以及合成的G-四链体AS 1411。研究意义：本文综述了影响G-四链体的因素以及人工合成的G-四链体AS 1411的功能。它还讨论了使用G-四链体的药物输送在肿瘤治疗。
G-quadruplexes form folded structures because of tandem repeats of guanine sequences in DNA or RNA. They adopt a variety of conformations, depending on many factors, including the type of loops and cations, the nucleotide strand number, and the main strand polarity of the G-quadruplex. Meanwhile, the different conformations of G-quadruplexes have certain influences on their biological functions, such as the inhibition of transcription, translation, and DNA replication. In addition, G-quadruplex binding proteins also affect the structure and function of Gquadruplexes. Some chemically synthesized G-quadruplex sequences have been shown to have biological activities. For example, bimolecular G-quadruplexes of AS1411 act as targets of exogenous drugs that inhibit the proliferation of malignant tumours. G-quadruplexes are also used as vehicles to deliver nanoparticles. Thus, it is.important to identify the factors that influence G-quadruplex structures and maintain the stability of G-quadruplexes. Herein, we mainly discuss the factors influencing G-quadruplexes and the synthetic G-quadruplex, AS1411. Significance of the study: This review summarizes the factors that influence G-quadruplexes and the functions of the synthetic G-quadruplex, AS1411. It also discusses the use of G-quadruplexes for drug delivery in tumour therapy.