Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma.
Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma.
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低分化的人胃癌比高分化的胃癌对抗肿瘤药物更敏感。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
K. Sugimachi
中科院分区：
文献类型：
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作者：
Y. Maehara;H. Anai;H. Kusumoto;K. Sugimachi
采用体外琥珀酸脱氢酶抑制试验，对41例低分化胃癌组织和16例高分化胃癌组织的化疗药物敏感性进行了比较。这些在手术时获得的人体组织暴露于六种不同的抗肿瘤药物：卡波醌（CQ）、阿霉素（ADM）、丝裂霉素C（MMC）、阿克拉霉素A（ACR）、顺铂（DDP）和5-氟尿嘧啶（5-FU）。当暴露于药物的细胞的琥珀酸脱氢酶（SD）活性在暴露的第3天降低至对照细胞的50%以下时，化学敏感性被确定为阳性。ADM、MMC、DDP和5-FU处理后，低分化组织中SD活性明显低于高分化组织。低分化组织对所有6种抗肿瘤药物的敏感率均高于高分化组织。63%的低分化组织在同一组织中对三种以上的抗肿瘤药物敏感，但在高分化组织中这一比例仅为19%。低分化癌组织对所有药物的耐药率为20%，高分化癌组织为31%。这表明，与分化良好的胃癌患者相比，分化差的胃癌患者可能会对抗肿瘤药物表现出更好的反应。
The chemosensitivities of 41 poorly differentiated gastric cancer tissues were compared with that of 16 well differentiated tissues, using the in vitro succinate dehydrogenase inhibition test. These human tissues obtained at the time of surgery were exposed to six different antitumor drugs: carboquone (CQ), adriamycin (ADM), mitomycin C (MMC), aclacinomycin A (ACR), cisplatin (DDP) and 5-fluorouracil (5-FU). The chemosensitivity was determined as positive when the succinate dehydrogenase (SD) activity of the drug exposed cells was decreased to below 50% of that of control cells, on day 3 of exposure. Decrease in SD activity was remarkable in the poorly differentiated tissues, compared to the well differentiated tissues, exposed to ADM, MMC, DDP and 5-FU. The sensitive rates were higher in the poorly differentiated tissues than in the well differentiated tissues, against all six antitumor drugs. Sixty-three per cent of the poorly differentiated tissues were sensitive to more than three antitumor drugs, in an identical tissue, but the rate was only 19% in the well differentiated tissues. The resistant rates to all drugs tested were 20% in the poorly differentiated and 31% in the well differentiated tissues. This would indicate that patients with a poorly differentiated gastric cancer will probably show a better response to antitumor drugs, compared to those with a well differentiated type.