Carboline Alkaloids from Trigonostemon lii
Carboline Alkaloids from Trigonostemon lii
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三角百草中的咔啉生物碱
DOI：
10.1055/s-0029-1185505
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发表时间：
2009-08-01
期刊：
影响因子：
2.7
通讯作者：
Hao, Xiao-Jiang
中科院分区：
文献类型：
--
作者：
Hu, Xu-Jia;Di, Ying-Tong;Hao, Xiao-Jiang
从胡芦巴（Trigonostemonlii）的根和茎中分离得到三种类型的六个新咔啉生物碱，即胡芦巴素A-F（1-6）。通过波谱分析鉴定了它们的结构。β-咔啉类生物碱在三角蕊属植物中首次发现。Trigonostemonine F（6）对HL-60有中等的细胞毒活性，IC_（50）值为16 μ M。
Three types with six new carboline alkaloids, trigonostemonines A - F (1-6), were isolated from the roots and stems of Trigonostemon lii. Their structures were elucidated by spectroscopic analyses. It is the first time that beta-carboline alkaloids have been reported in Trigonostemon species. Trigonostemonine F (6) exhibited moderate cytotoxic activity against HL-60 with an IC50 value of 16 mu M.