Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk
Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk
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DOI：
10.1097/mpa.0b013e318053e7d3
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发表时间：
2007-08-01
期刊：
影响因子：
2.9
通讯作者：
Abbruzzese, James L.
中科院分区：
文献类型：
--
作者：
Lo, An-Chi;Soliman, Amr S.;Abbruzzese, James L.
目的：本研究调查了埃及胰腺癌的流行病学。方法：我们从 194 名胰腺癌病例和 194 名对照者中获得了有关吸烟、职业、医疗和生殖史的详细信息。结果：与不吸烟相比，单独吸烟或与其他吸烟方法（例如水烟、雪茄）结合吸烟与风险（比值比）增加相关。 [或]，4.5 和 7.8； 95% 置信区间 [95% CI] 分别为 1.9-10.7 和 3.0-20.6）。被动吸烟也是一个重要的危险因素（OR，6.0-1 95% CI，2.4-14.8）。接触农药的受试者患胰腺癌的风险升高（OR，2.6；95% CI，0.97-7.2）。先前诊断糖尿病长达 10 年与较高风险相关（OR，5.4；95% CI，1.5-19.9）。对于女性来说，生育 7 次或以上活产且哺乳时间为 144 个月或更长与风险降低相关（OR，0.5 和 0.2；95% CI，分别为 0.2-1.3 和 0.1-0.9）。在埃及，没有发现家族史、过敏或肥胖与胰腺癌之间存在关联。结论：多种烟草消费方式、被动吸烟、农药暴露和糖尿病与胰腺癌风险增加相关。延长哺乳期和增加胎次与胰腺癌风险降低相关。
Objectives: This study examined the epidemiology of pancreatic cancer in Egypt.Methods: We obtained detailed information on smoking, occupational, medical, and reproductive histories from 194 pancreatic cancer cases and 194 controls.Results: Compared with not smoking, smoking cigarettes alone or in conjunction with other smoking methods (eg, water pipe, cigar) was associated with an increased risk (odds ratio [OR], 4.5 and 7.8; 95% confidence interval [95% CI], 1.9-10.7 and 3.0-20.6, respectively). Passive smoking was also a significant risk factor (OR, 6.0-1 95% CI, 2.4-14.8). The risk of pancreatic cancer was elevated among subjects exposed to pesticides (OR, 2.6; 95% CI, 0.97-7.2). A prior diagnosis of diabetes mellitus for a period of 10 years was associated with higher risk (OR, 5.4; 95% CI, 1.5-19.9). For women, having 7 or more live births and lactating for 144 months or longer were associated with a reduced risk (OR, 0.5 and 0.2; 95% CI, 0.2-1.3 and 0.1-0.9, respectively). No association was found between family history, allergy, or obesity and pancreatic cancer in Egypt.Conclusions: Multiple tobacco consumption methods, passive smoking, pesticide exposures, and diabetes are associated with an increased risk for pancreatic cancer. Prolonged lactation and increased parity are associated with a reduced risk for pancreatic cancer.