COMPARTMENTATION OF THE CEREBELLAR NUCLEI OF THE MOUSE
COMPARTMENTATION OF THE CEREBELLAR NUCLEI OF THE MOUSE
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DOI：
10.1016/j.neuroscience.2009.03.037
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发表时间：
2009-06-16
期刊：
影响因子：
3.3
通讯作者：
Hawkes, R.
中科院分区：
文献类型：
--
作者：
Chung, S. -H.;Marzban, H.;Hawkes, R.
小脑核整合来自浦肯野细胞的抑制性输入和来自苔藓和攀缘纤维侧枝的兴奋性输入，是小脑唯一的输出。大量的研究表明，小脑皮质被高度划分成数百个遗传决定的、可重复的地形单位--横带和旁带--这些单位可以通过许多分子的表达模式来识别。浦肯野细胞条纹投射到小脑核。然而，没有已知的相称地形复杂性小脑核。相反，传统的解剖学描述确定了四个主要的细分内侧，前和后插入，和外侧核，连同一些核内的细分。为了开始解决明显的复杂性差距，我们使用了一组抗原和转基因，以揭示小鼠小脑核中可重复的分子异质性。基于单个和组合的差异表达模式，构建了一个新的小脑核地形图。这揭示了小脑核的细分成至少12个可重复的表达域。我们假设，这种异质性是对应的区域和条纹的小脑皮质。(C)2009年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The cerebellar nuclei integrate inhibitory input from Purkinje cells with excitatory input from mossy and climbing fiber collaterals and are the sole cerebellar output. Numerous studies have shown that the cerebellar cortex is highly compartmentalized into hundreds of genetically determined, reproducible topographic units-transverse zones and parasagittal stripes-that can be identified through the expression patterns of numerous molecules. The Purkinje cell stripes project to the cerebellar nuclei. However, there is no known commensurate topographic complexity in the cerebellar nuclei. Rather, conventional anatomical descriptions identify four major subdivisions-the medial, anterior and posterior interposed, and lateral nuclei-together with a few intranuclear subdivisions. To begin to address the apparent complexity gap, we have used a panel of antigens and transgenes to reveal a reproducible molecular heterogeneity in the mouse cerebellar nuclei. Based on the differential expression patterns, singly and in combination, a new cerebellar nuclear topographic map has been constructed. This reveals the subdivision of the cerebellar nuclei into at least 12 reproducible expression domains. We hypothesize that such heterogeneity is the counterpart of the zones and stripes of the cerebellar cortex. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.