ANTIGENIC VARIATION DURING TRYPANOSOMA-VIVAX INFECTIONS OF DIFFERENT HOST SPECIES
ANTIGENIC VARIATION DURING TRYPANOSOMA-VIVAX INFECTIONS OF DIFFERENT HOST SPECIES
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DOI：
10.1017/s0031182000063447
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发表时间：
1986-02-01
期刊：
影响因子：
2.4
通讯作者：
BARRY, JD
中科院分区：
文献类型：
--
作者：
BARRY, JD
本文研究了5个种27只动物血清中对间日锥虫20多种可变抗原型（VATs）的特异性裂解活性的出现顺序。对于每个宿主物种有一个特征的感染过程中，寄生虫病的高度和持续时间和致病性的差异。抗原变异的序列在所有宿主物种中是相似的，一些增值税一贯引起的反应比其他更快。主要的组，包括增值税，显然是在前3周内开发，根据在此期间内的血液中的锥虫的总数在大小上不同，这表明有一个频谱，而不是离散的分组，在层次结构的增值税的表达。几乎没有证据表明宿主物种之间的增值税外观存在差异。T.的抗原变异序列。间日疟原虫似乎是由寄生虫而不是宿主物种决定的。
The sequence of appearance of specific lytic activity against more than 20 variable antigen types (VATs) of Trypanosoma vivax in the serum of 27 animals belonging to 5 species has been examined. For each host species there was a characteristic course of infection, with differences in height and duration of parasitaemia and in pathogenicity. The sequence of antigenic variation was similar in all host species, with some VATs consistently eliciting response more rapidly than others. The predominant group, comprising VATs which apparently developed within the first 3 weeks, varied in size according to the total number of trypanosomes in the bloodstream within that period, suggesting there is a spectrum, rather than discrete groupings, in the hierarchy of VAT expression. There was very little evidence for differences in appearance of VATs between host species. The sequence of antigenic variation in T. vivax seems to be determined by the parasite rather than the host species.