Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients With Chronic Periodontitis: A Split-Mouth Randomized Controlled Clinical Trial
Additive Effect of Plasma Rich in Growth Factors With Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients With Chronic Periodontitis: A Split-Mouth Randomized Controlled Clinical Trial
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DOI：
10.1902/jop.2017.160824
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发表时间：
2017-09-01
影响因子：
4.3
通讯作者：
Prakasam, Gopinath
中科院分区：
文献类型：
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作者：
Ravi, Sheethalan;Malaiappan, Sankari;Prakasam, Gopinath
背景：牙周组织再生是指牙周组织完全恢复其原有的结构和功能。富含生长因子的血浆（Plasma rich in growth factors，PRGF）是一种生长因子的浓缩悬浮液，可促进牙周组织的修复。本研究的目的是评估PRGF联合引导组织再生（GTR）与单纯引导组织再生（GTR）治疗慢性牙周炎（CP）患者骨内缺损（IBD）的效果。方法：将14例CP患者（n=14）随机分为试验组（PRGF+GTR）和对照组（单纯引导组织再生）。在基线和6个月后进行的临床和放射学评估包括：1）牙龈指数（GI），2）探诊深度（PD），3）临床附着水平（CAL），4）放射学缺损深度，5）骨填充。结果：基线和6个月后测量的参数比较显示，对照组平均PD减少3.37 ± 1.62 mm（P
Background: Periodontal regeneration can be defined as complete restoration of lost periodontal tissues to their original architecture and function. A variety of treatment modalities have been proposed to achieve it. Plasma rich in growth factors (PRGF) is a concentrated suspension of growth factors that promotes restoration of lost periodontal tissues. The objective of the present study is to assess the effect of PRGF associated with guided tissue regeneration (GTR) versus GTR only in the treatment of intrabony defects (IBDs) in patients with chronic periodontitis (CP).Methods: Patients with CP (n=14) with 42 contralateral 2-and 3-wall eddefects were randomly assigned to test (PRGF+GTR) and control (GTR alone) treatment groups. Clinical and radiographic assessments performed at baseline and after 6 months were: 1) gingival index (GI),2)probing depth (PD),3)clinical attachment level (CAL),4)radiologicdefect depth, and 5) bone fill.Results: Comparison of parameters measured at baseline and after 6 months showed mean PD reduction of 3.37 +/- 1.62mm in the control group (P