HIGH-FREQUENCY NETWORK OSCILLATION IN THE HIPPOCAMPUS
HIGH-FREQUENCY NETWORK OSCILLATION IN THE HIPPOCAMPUS
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DOI：
10.1126/science.1589772
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发表时间：
1992-05-15
期刊：
影响因子：
56.9
通讯作者：
WISE, K
中科院分区：
文献类型：
--
作者：
BUZSAKI, G;HORVATH, Z;WISE, K
CA1海马区锥体细胞在行为不动、损毁行为和慢波睡眠中表现出短暂的网络振荡(200赫兹)。同时，多点记录显示了群体振荡期间神经元活动的时间和空间一致性。参与的锥体细胞以低于群体振荡频率的速率放电，其动作电位被锁相到同时记录的振荡场电位的负相。相反，在场振荡过程中，中间神经元以群体频率放电。因此，相互协作的CA1锥体细胞的同步输出可能有助于诱导海马靶结构中的突触增强。
Pyramidal cells in the CA1 hippocampal region displayed transient network oscillations (200 hertz) during behavioral immobility, consummatory behaviors, and slow-wave sleep. Simultaneous, multisite recordings revealed temporal and spatial coherence of neuronal activity during population oscillations. Participating pyramidal cells discharged at a rate lower than the frequency of the population oscillation, and their action potentials were phase locked to the negative phase of the simultaneously recorded oscillatory field potentials. In contrast, interneurons discharged at population frequency during the field oscillations. Thus, synchronous output of cooperating CA1 pyramidal cells may serve to induce synaptic enhancement in target structures of the hippocampus.