Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population
Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population
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DOI：
10.1007/s00535-008-2219-0
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发表时间：
2008-10
影响因子：
6.3
通讯作者：
T. Torisu;T. Matsumoto;Y. Takata;T. Ansai;I. Soh;S. Awano;Ikuo Nakamichi;S. Kagiyama;K. Sonoki;A. Yoshida;T. Hamasaki;M. Iida;T. Takehara
中科院分区：
文献类型：
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作者：
T. Torisu;T. Matsumoto;Y. Takata;T. Ansai;I. Soh;S. Awano;Ikuo Nakamichi;S. Kagiyama;K. Sonoki;A. Yoshida;T. Hamasaki;M. Iida;T. Takehara
背景幽门螺杆菌（Helicobacter pylori，HP）感染与体重指数（body mass index，BMI）的关系一直存在争议。一些报告表明根除HP感染会导致BMI增加。相反，流行病学病例对照研究未能显示HP感染与BMI之间的关联。因此，我们调查是否HP和萎缩性胃炎（AG）与BMI.MethodsA共617人被招募的BMI，血清瘦素，胃蛋白酶原（PGs）I和II，和IgG抗体HP（HP-IgG）的测量。结果根据PG值（PG I ≤ 70 ng/ml，PG I/II ≤3.0）将受试者分为AG阳性组和AG阴性组。校正性别和年龄后，AG阳性组BMI显著低于AG阴性组（23.47 ± 3.05vs.24.18 ± 3.25，P = 0.010）。当受试者根据HP-IgG分为两组时，HP-IgG阳性组的BMI倾向于较低，但差异不大。当受试者被分为四组的AG和HP-IgG的不同组合，体重指数是最低的AG阳性和HP-IgG阴性group.ConclusionsBMI与AG，诊断的PG，但不与HP感染状态。这些结果表明HP感染通过萎缩性胃炎影响BMI。
BackgroundThe relationship betweenHelicobacter pylori(HP) infection and body mass index (BMI) is controversial. Several reports have indicated that eradication of HP infection induces an increase in BMI. In contrast, epidemiological case-control studies have failed to show an association between HP infection and BMI. Therefore, we investigated whether HP and atrophic gastritis (AG) were associated with BMI.MethodsA total of 617 individuals were recruited for the measurements of BMI, serum leptin, pepsinogens (PGs) I and II, and IgG antibody to HP (HP-IgG). BMI and leptin of the subjects were compared when the subjects were stratified by HP-IgG and PGs.ResultsThe subjects were divided into AG-positive and AG-negative groups according to PGs (AG-positive: PG I ≤ 70 ng/ml and PG I/II ratio ≤3.0). BMI after adjusting for sex and age was significantly lower in the AG-positive group than in the AG-negative group (23.47 ± 3.05 vs. 24.18 ± 3.25,P= 0.010). When the subjects were divided into two groups according to HP-IgG, BMI tended to be lower in the HP-IgG-positive group, though the difference was not large. When the subjects were divided into four groups for different combinations of AG and HP-IgG, BMI was the lowest in the AG-positive and HP-IgG-negative group.ConclusionsBMI was associated with AG, as diagnosed by PGs, but not with HP infection status. These results mean that HP infection affects BMI via atrophic gastritis.