Roles of Wnt Target Genes in the Journey of Cancer Stem Cells.
Roles of Wnt Target Genes in the Journey of Cancer Stem Cells.
复制标题
Wnt靶基因在肿瘤干细胞过程中的作用
DOI：
10.3390/ijms18081604
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发表时间：
2017-07-25
影响因子：
5.6
通讯作者：
Nam JS
中科院分区：
文献类型：
--
作者：
Kim JH;Park SY;Jun Y;Kim JY;Nam JS
Wnt/β-catenin信号在肿瘤干细胞(CSCs)中的重要性已得到公认，但其调节CSCs生物学功能和促进癌症进展的机制仍不清楚。因此，为了了解Wnt控制干性的复杂机制，基于基因集浓缩的方法，通过分析多种类型转移癌的遗传特征，建立了Wnt的特异性下游靶基因。通过对Wnt靶基因的分子功能的研究，从CSC从起始到转移的动态过程来解释Wnt的生物学作用。WNT信号通过从正常干细胞或非CSCs产生CSCs并增强原发区域的持续生长来参与癌症的启动，而原发区域对抗癌治疗具有抵抗力。此外，它还帮助CSCs侵袭周围组织并进入血流，在此期间，Wnt信号通路的负反馈使CSCs处于适合生存的休眠状态。当CSCs到达遥远的器官时，Wnt信号的另一次爆发诱导CSCs成功地重新启动和定植。这种对WNT靶基因的全面理解为WNT如何允许CSCs在癌症进展过程中发生变化提供了一个可信的解释。
The importance of Wnt/β-catenin signaling in cancer stem cells (CSCs) has been acknowledged; however, the mechanism through which it regulates the biological function of CSCs and promotes cancer progression remains elusive. Hence, to understand the intricate mechanism by which Wnt controls stemness, the specific downstream target genes of Wnt were established by analyzing the genetic signatures of multiple types of metastatic cancers based on gene set enrichment. By focusing on the molecular function of Wnt target genes, the biological roles of Wnt were interpreted in terms of CSC dynamics from initiation to metastasis. Wnt signaling participates in cancer initiation by generating CSCs from normal stem cells or non-CSCs and augmenting persistent growth at the primary region, which is resistant to anti-cancer therapy. Moreover, it assists CSCs in invading nearby tissues and in entering the blood stream, during which the negative feedback of the Wnt signaling pathway maintains CSCs in a dormant state that is suitable for survival. When CSCs arrive at distant organs, another burst of Wnt signaling induces CSCs to succeed in re-initiation and colonization. This comprehensive understanding of Wnt target genes provides a plausible explanation for how Wnt allows CSCs variation during cancer progression.
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影响因子：
16.6
作者：
Avgustinova A;Iravani M;Robertson D;Fearns A;Gao Q;Klingbeil P;Hanby AM;Speirs V;Sahai E;Calvo F;Isacke CM
通讯作者：
Isacke CM
DOI：
10.1126/science.aac9935
发表时间：
2016-04-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Casey SC;Tong L;Li Y;Do R;Walz S;Fitzgerald KN;Gouw AM;Baylot V;Gütgemann I;Eilers M;Felsher DW
通讯作者：
Felsher DW
影响因子：
3.7
作者：
Bhat AA;Sharma A;Pope J;Krishnan M;Washington MK;Singh AB;Dhawan P
通讯作者：
Dhawan P
影响因子：
2.9
作者：
Choe Y;Pleasure SJ
通讯作者：
Pleasure SJ
影响因子：
--
作者：
Chandrakesan P;Weygant N;May R;Qu D;Chinthalapally HR;Sureban SM;Ali N;Lightfoot SA;Umar S;Houchen CW
通讯作者：
Houchen CW