Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer
Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer
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DOI：
10.1016/s0140-6736(03)13365-x
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发表时间：
2003-05-17
期刊：
影响因子：
168.9
通讯作者：
Griggs, J
中科院分区：
文献类型：
--
作者：
Guttuso, T;Roscoe, J;Griggs, J
在一份轶事报告中，一名乳腺癌患者在服用抗惊厥药加巴喷丁后，化疗引起的恶心完全消退。在此基础上，我们进行了一项开放标签研究，其中9例乳腺癌患者在每隔一次化疗的基础上口服加巴喷丁300 mg，每日3次。9名患者中有6名报告延迟恶心峰值至少改善了3分（在8分恶心量表上），3名患者在服用加巴喷丁时恶心完全消退。这一初步证据表明，加巴喷丁可能在治疗化疗引起的恶心中发挥作用。
In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin. On this basis, we did an open-label study in which oral gabapentin 300 mg thrice daily was given for every other chemotherapy treatment in nine patients with breast cancer. Six of the nine reported at least a three-point improvement in peak delayed nausea (on an eight-point nausea scale), and three patients had complete resolution of nausea when taking gabapentin. This preliminary evidence shows that gabapentin might have a role in treatment of chemotherapy-induced nausea.