Predicting factors for disappearance of anti-mutated citrullinated vimentin antibodies in sera of patients with rheumatoid arthritis
Predicting factors for disappearance of anti-mutated citrullinated vimentin antibodies in sera of patients with rheumatoid arthritis
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DOI：
10.1080/14397595.2019.1621439
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发表时间：
2019-06-11
影响因子：
2.2
通讯作者：
Mimori, Tsuneyo
中科院分区：
文献类型：
--
作者：
Ishigooka, Nozomi;Fujii, Takao;Mimori, Tsuneyo
目的：我们的目的是确定类风湿关节炎（RA）患者血清中抗突变瓜氨酸波形蛋白抗体（抗MCV Ab）消失的预测因素。研究方法：2013年，入组了95例基线时疾病活动性评分和红细胞沉降率为中度至重度（DAS 28-ESR >= 3.2）的RA患者。测量了2013年和2014年抗MCV Ab和抗环瓜氨酸肽（抗CCP）Ab的滴度。回顾性研究抗MCV消失与疾病活动性、治疗、间质性肺病（ILD）和ILD血清标志物之间的关系。多因素分析确定抗MCV消失的预测因素。结果：抗CCP抗体阳性率无明显变化，抗MCV抗体转阴18例（19.0%）。连续使用生物学疾病缓解抗风湿药物、泼尼松龙剂量（>= 5.0 mg/d）和低KL-6水平（
Objectives: We aimed to determine the predicting factors for disappearance of anti-mutated citrullinated vimentin antibody (anti-MCV Ab) in sera from rheumatoid arthritis (RA) patients. Methods: In 2013, 95 RA patients whose Disease Activity Score with erythrocyte sedimentation rate were moderate to severe (DAS28-ESR >= 3.2) at baseline were enrolled. Titers of anti-MCV Ab and anti-cyclic citrullinated peptide (anti-CCP) Ab for 2013 and 2014 were measured. The association of anti-MCV disappearance with disease activity, treatment, interstitial lung disease (ILD), and serum markers of ILD were retrospectively examined. Predicting factors of anti-MCV disappearance were determined by multivariable analysis. Results: While anti-CCP positivity rate did not change during the year, anti-MCV Ab changed from positive to negative in 18 patients (=19.0%). Continuous biological disease-modifying anti-rheumatic drug use, prednisolone dose (>= 5.0 mg daily), and low KL-6 level (