Serum Tsukushi levels are elevated in newly diagnosed type 2 diabetic patients
Serum Tsukushi levels are elevated in newly diagnosed type 2 diabetic patients
复制标题
新诊断的 2 型糖尿病患者血清 Tsukushi 水平升高
DOI：
10.1016/j.diabres.2021.108987
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Guoyue Yuan
中科院分区：
文献类型：
--
作者：
Yanyan Li;Xunan Wu;Xia Deng;Panpan Zhang;Haoxiang Li;Ke Chen;Danping Wu;Tian Gu;Chenxi Wang;Li Zhao;Dong Wang;Ling Yang;Guoyue Yuan
Tsukushi是一种新发现的肝细胞因子，近年来被认为是一种有效的脂质代谢和能量平衡调节剂，但Tsukushi在糖尿病中的作用几乎还不清楚。首次检测初诊2型糖尿病患者血清Tsukushi水平，探讨Tsukushi与各种代谢指标的关系。方法共纳入172例受试者，其中初诊2型糖尿病患者86例，口服葡萄糖耐量试验正常者86例。用ELISA法检测血清中的Tsukushi。采用稳态模型评价胰岛素抵抗、胰岛β细胞功能和胰岛素敏感性（HOMA-IR，HOMA-β），Stumvoll胰岛素敏感性指数（ISistumvoll）和Stumvoll代谢清除率结果2型糖尿病患者血清Tsukushi水平显著高于糖耐量正常者[1.22（0.86，1.74）vs 0.8（0.5，1.38）ng/mL; P <0.001]。多元回归分析显示BMI、OGTT后2 h血糖和TC是影响Tsukushi的独立相关因素。Logistic回归分析显示，Tsukushi与2型糖尿病的发病风险独立相关。结论Tsukushi在2型糖尿病患者循环中的水平显著升高，提示Tsukushi可能在2型糖尿病的发病中起作用。
AimsTsukushi, a newly identified hepatokine, has been recently characterized as a potent modifier in lipid metabolism and energy homeostasis, but the role of Tsukushi in diabetes remains almost unknown. We detected for the first time the serum Tsukushi levels in newly diagnosed type 2 diabetes, exploring the relationship between Tsukushi and various metabolic parameters.MethodsA total of 172 participants were recruited, including 86 patients with newly diagnosed type 2 diabetes and 86 subjects with normal glucose tolerance according to oral glucose tolerance test. Serum Tsukushi was measured by ELISA. The insulin resistance, pancreas β-cell function and insulin sensitivity were determined by homeostasis model assessment (HOMA-IR, HOMA-β), Stumvoll insulin sensitivity index (ISIstumvoll) and Stumvoll metabolic clearance rate (MCRstumvoll).ResultsSerum Tsukushi was significantly higher in type 2 diabetes than in normal glucose tolerance [1.22(0.86,1.74) vs 0.8(0.5,1.38) ng/mL;P< 0.001]. Multiple regression analysis showed that BMI, 2-h post-OGTT glucose and TC were independently related factors influencing Tsukushi. Logistic regression analyses demonstrated that Tsukushi was associated with higher risk of type 2 diabetes independently.ConclusionsCirculating Tsukushi levels significantly increase in patients with type 2 diabetes, which suggest that Tsukushi may play a role in type 2 diabetes pathogenesis.