The Genetics of Strabismus
The Genetics of Strabismus
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DOI：
10.3368/aoj.51.1.67
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发表时间：
2001-01
期刊：
影响因子：
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通讯作者：
E. Traboulsi
中科院分区：
文献类型：
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作者：
E. Traboulsi
在他的早期实践中，John PrattJohnson博士意识到斜视的基因决定因素的重要性，并倡导在有眼部错位家族史的个人中迅速检测出斜视。1尽管从古希腊时代起，斜视的遗传成分就因其家族聚集性而被怀疑，但直到1923年克劳德·沃思才提出假设：“融合能力的缺陷是斜视的根本原因，是遗传因素。。.“.2他继续说”。。。在这个根本原因的存在下，眼睛处于一种不稳定的平衡状态，在轻微的挑衅下向内或向外眯眼。这最后一种理论还有待验证。然而，很明显，遗传性解剖、神经和/或融合缺陷必须是所有形式的家族性和可能是孤立的斜视病例的基础。大量的
Early in his practice, Dr. John PrattJohnson realized the importance of genetic determinants of strabismus and advocated the prompt detection of strabismus in individuals with a family history of ocular misalignment.1 Although a genetic component to strabismus had been suspected since ancient Greek times because of its familial aggregation, it was not until 1923 that Claude Worth postulated that “a defect in the fusion faculty is the essential cause of squint and is the inherited factor. . .”.2 He continued to state that “. . . in the presence of this fundamental cause, the eyes are in a state of unstable equilibrium to squint either inwards or outwards on slight provocation.” This last theory remains to be proven. It is however clear that inherited anatomical, innervational and/or fusional defects have to underlie all forms of familial and probably isolated cases of strabismus. A large number of