Hydrogen sulfide-mediated myocardial pre- and post-conditioning.
Hydrogen sulfide-mediated myocardial pre- and post-conditioning.
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DOI：
10.1586/ecp.10.56
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发表时间：
2011-01
影响因子：
4.4
通讯作者：
Lefer DJ
中科院分区：
文献类型：
--
作者：
Predmore BL;Lefer DJ
冠状动脉疾病是西方世界发病率和死亡率的主要原因。急性心肌梗死是由冠状动脉粥样硬化引起的，是冠状动脉疾病的一种严重且往往致命的后果，导致心肌细胞死亡。心肌预适应和后适应是两种显著减少细胞死亡数量的治疗策略。硫化氢最近被发现是一种有效的心脏保护信号分子，是一种非常有效的前调理剂和后调理剂。本文将探讨以硫化氢为基础的预处理和后适应所涉及的心脏保护信号通路。
Coronary artery disease is a major cause of morbidity and mortality in the Western world. Acute myocardial infarction, resulting from coronary artery atherosclerosis, is a serious and often fatal consequence of coronary artery disease, resulting in cell death in the myocardium. Pre- and post-conditioning of the myocardium are two treatment strategies that reduce the amount of cell death significantly. Hydrogen sulfide has recently been identified as a potent cardioprotective signaling molecule, which is a highly effective pre- and post-conditioning agent. The cardioprotective signaling pathways involved in hydrogen sulfide-based pre- and post-conditioning will be explored in this article.