Estrogen induces estrogen receptor alpha expression and hepatocyte proliferation in the livers of male mice
Estrogen induces estrogen receptor alpha expression and hepatocyte proliferation in the livers of male mice
复制标题
DOI：
10.1111/gtc.12214
复制
发表时间：
2015-03-01
期刊：
影响因子：
2.1
通讯作者：
Imai, Takeshi
中科院分区：
文献类型：
--
作者：
Uebi, Tatsuya;Umeda, Makoto;Imai, Takeshi
雌激素在性发育、生长、生殖和性别分化中起着关键作用，并与各种组织中的许多生理过程有关。雌激素的大多数作用是由雌激素受体α（ER）、β（ER）和G蛋白偶联受体30（GPR30）介导的。已知肝脏是雌激素信号传导的靶组织，但这种信号传导的生理作用还没有很好地表征。通过对雌二醇（E2）处理的肝细胞系和小鼠的分析，我们发现E2信号转导控制肝细胞增殖。重要的是，我们的数据表明，通过ER介导的E2信号传导对于部分肝切除术（PH）后的有效肝再生至关重要。PH迅速诱导门静脉周围肝细胞循环E2和ER转录显着增加，早在肝细胞增殖开始之前。总之，我们的研究结果表明，增加E2是触发肝再生的起始信号之一。我们认为，E2治疗可能有利于刺激人类肝再生。
Estrogens play pivotal roles in sexual development, growth, reproduction, and sex differentiation and have been implicated in a number of physiological processes in various tissues. Most of the effects of estrogens are mediated by the estrogen receptors alpha (ER), beta (ER), and G protein-coupled receptor 30 (GPR30). The liver is known to be a target tissue for estrogen signaling, but the physiological role of this signaling is not well characterized. Through analyses of an estradiol (E2)-treated hepatocyte cell line and mice, we showed that E2 signaling controls hepatocyte proliferation. Importantly, our data showed that the E2 signaling that is mediated through ER is crucial for efficient liver regeneration after partial hepatectomy (PH). PH rapidly induced marked increases in circulating E2 and ER transcripts in periportal hepatocytes, well before the onset of hepatocyte proliferation. Taken together, our results indicate that increased E2 is one of the initiating signals that trigger liver regeneration. We suggest that E2 treatment could be beneficial for stimulating liver regeneration in humans.