Alternative biomarkers for assessing glycemic control in diabetes: fructosamine, glycated albumin, and 1,5-anhydroglucitol.
Alternative biomarkers for assessing glycemic control in diabetes: fructosamine, glycated albumin, and 1,5-anhydroglucitol.
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DOI：
10.6065/apem.2015.20.2.74
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发表时间：
2015-06-01
影响因子：
2.2
通讯作者：
Lee, Ji-Eun
中科院分区：
文献类型：
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作者：
Lee, Ji-Eun
由于糖化血红蛋白（HbA 1c）测定的局限性，对替代血糖生物标志物（包括果糖胺、糖化白蛋白（GA）、1，5-脱水葡萄糖醇（1，5-AG））的关注日益增加。重要的是要认识到HbA 1c水平可能难以解释的情况。血清果糖胺和GA已被提出用于监测短期血糖控制的有用工具。这些生物标志物不仅能很好地反映血液病患者的血糖控制情况，而且能反映餐后血糖波动情况。血清1，5-AG可用于估计日内血糖变化。使用这些非传统的测试可以更有助于糖尿病的管理，作为传统措施的补充。需要进一步进行更大规模的队列研究，以确定非传统生物标志物是否对糖尿病的早期诊断、管理和预防糖尿病并发症具有潜在的效用。
The growing attention to alternative glycemic biomarkers including fructosamine, glycated albumin (GA), 1,5-anhydroglucitol (1,5-AG), is attributable to the limitations of the glycated hemoglobin (HbA1c) assay. It is important to recognize the conditions in which HbA1c levels may be difficult to interpret. Serum fructosamine and GA have been proposed useful tools for monitoring of short-term glycemic control. These biomarkers not only reflect well glycemic control in hematologic disorder, but also represent postprandial glucose fluctuation. Serum 1,5-AG may be useful for estimating within-day glucose variation. Use of these nontraditional tests can be more helpful in the management of diabetes as complement traditional measures. Further larger cohort studies are warranted to determine whether nontraditional biomarkers have potential utility for early diagnosis, management of diabetes, and prevention of diabetic complications.