Histological type of Thorotrast‐induced liver tumors associated with the translocation of deposited radionuclides
Histological type of Thorotrast‐induced liver tumors associated with the translocation of deposited radionuclides
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与沉积的放射性核素易位相关的Thorotrast诱发的肝脏肿瘤的组织学类型
DOI：
10.1111/j.1349-7006.2009.01401.x
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发表时间：
2010
期刊：
影响因子：
5.7
通讯作者：
M. Fukumoto
中科院分区：
文献类型：
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作者：
Yoichiro Yamamoto;J. Chikawa;Yoshinobu Uegaki;N. Usuda;Y. Kuwahara;M. Fukumoto
已知暴露于内部沉积的放射性核素会诱发各种组织学类型的恶性肿瘤。Thorotrast是一种放射性二氧化钍（232 ThO 2）的胶体悬浮液，可发射α粒子，在第二次世界大战期间被用作放射造影剂。已知Thorotrast在注射后数十年可诱导肝脏肿瘤，特别是肝内胆管癌（ICC）和血管肉瘤（AS）。因此，注射Thorotrast的患者组成了一个合适的研究组，以了解内部电离辐射损伤的生物学效应。对Thorotrast诱导的ICC（T-ICC）和Thorotrast诱导的AS（T-AS）的非肿瘤肝切片进行放射自显影和X射线荧光光谱法（XRF）。放射自显影显示，T-ICC肝非肿瘤部分的α径迹数与沉积钍（232 Th）量的回归线斜率高于T-AS。XRF显示，T-ICC的非肿瘤肝组织中镭（Ra）与钍（Th）的强度比显著高于T-AS。此外，T-ICC病例中计算的死亡时平均228 Ra/232 Th放射性比值也显著高于T-AS病例。这表明放射性核素的代谢行为（如重新定位和排泄）以及沉积的放射性核素的含量是确定Thorotrast诱导的肝肿瘤组织学类型的主要因素。（Cancer Sci 2009）
Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types. Thorotrast, a colloidal suspension of radioactive Thorium dioxide (232ThO2) that emits alpha‐particles, was used as a radiographic contrast during World War II. Thorotrast is known to induce liver tumors, particularly intrahepatic cholangiocarcinoma (ICC) and angiosarcoma (AS), decades after injection. Therefore, patients injected with Thorotrast comprise a suitable study group to understand biological effects of internal ionizing radiation injury. Autoradiography and X‐ray fluorescence spectrometry (XRF) were carried out on non‐tumorous liver sections from Thorotrast‐induced ICC (T‐ICC) and Thorotrast‐induced AS (T‐AS). Autoradiography revealed that the slope of the regression line of the number of alpha tracks for the amount of deposited Thorium (232Th) was higher in non‐tumorous parts of the liver with T‐ICC than those with T‐AS. XRF showed that the intensity ratio of Radium (Ra) to Thorium (Th) in non‐tumorous liver tissue with T‐ICC was significantly higher than that with T‐AS. Furthermore, the mean 228Ra/232Th radioactivity ratio at the time of death calculated was also significantly higher in T‐ICC cases than in T‐AS cases. These suggest that the metabolic behavior of radionuclides such as relocation and excretion, as well as the content of deposited radionuclides, is a major factor in determining the histological type of Thorotrast‐induced liver tumors. (Cancer Sci 2009)
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