SHAPE AND VOLUME CHANGES IN ERYTHROCYTE-GHOSTS AND SPECTRIN-ACTIN NETWORKS
SHAPE AND VOLUME CHANGES IN ERYTHROCYTE-GHOSTS AND SPECTRIN-ACTIN NETWORKS
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DOI：
10.1083/jcb.86.2.371
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发表时间：
1980-01-01
影响因子：
7.8
通讯作者：
MEYER, DB
中科院分区：
文献类型：
--
作者：
JOHNSON, RM;TAYLOR, G;MEYER, DB
随着电解质浓度和pH值的变化，[人]红细胞鬼影可以表现出完整红细胞的一些特征形状。这些形状的变化伴随着体积的变化；两者都是可逆的，不依赖能量，不受巯基试剂的抑制。在孤立的无Triton-free谱蛋白-肌动蛋白晶格中也可以看到体积的减少，这表明该网络能够可逆收缩。红细胞膜底层细胞骨架大小的可逆变化显然可以控制细胞形状。
In response to changes in electrolyte concentration and pH, [human] erythrocyte ghosts can exhibit some of the characteristic shapes seen in the intact erythrocyte. These shape changes are accompanied by volume changes; both are reversible, not energy-dependent, and not inhibited by sulfhydryl reagents. The volume reduction can also be seen in isolated Triton-free spectrin-actin lattices, showing that this network is capable of reversible contraction. Reversible changes in size of the underlying cytoskeleton of the erythrocyte membrane apparently can control cell shape.