Familial characteristics of autoimmune and hematologic disorders in 8,406 multiple myeloma patients: A population-based case-control study
Familial characteristics of autoimmune and hematologic disorders in 8,406 multiple myeloma patients: A population-based case-control study
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DOI：
10.1002/ijc.21745
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发表时间：
2006-06-15
影响因子：
6.4
通讯作者：
Goldin, LR
中科院分区：
文献类型：
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作者：
Landgren, O;Linet, MS;Goldin, LR
进行了一项基于人群的病例对照研究，以评估与自身免疫性疾病个人史以及一级亲属发生自身免疫性疾病和选定血液学疾病相关的多发性骨髓瘤（MM）的风险。获得了瑞典（1958-1998年）诊断的所有（n = 8，406）MM病例的数据，其中包括病例（n = 22，490）和对照（n = 44，436）的直系亲属，16，543名匹配的对照和一级亲属。计算比值比（OR）以量化MM与32种自身免疫性疾病的个人/家族史相关的风险。恶性肿瘤的家族聚集性以亲属为队列，在边际生存模型中进行评估。有恶性贫血病史者（OR = 3.27; 2.22-4.83）和有系统性红斑狼疮家族史者（OR = 2.66; 1.12-6.32）MM的风险显著升高。与对照组相比，MM患者亲属中MM的相对危险度（RR）显著增加（RR = 1.67; 1.02-2.73），尤其是诊断时年龄≥ 65岁的先证者亲属（RR = 2.50; 1.19-5.27）。女性亲属（RR = 3.97; 1.54-10.2）和女性先证者亲属（RR = 3.74; 1.58-8.83）的风险增加近4倍。MM病例的亲属中未确定意义的单克隆丙种球蛋白病（MGUS）病例多于对照组，但数量太少，无法得出结论。一般没有增加MM的风险先证者的亲属有血液系统恶性肿瘤以外的MM。这些研究结果不支持个人/家族性自身免疫性疾病和MM之间的强相关性。然而，MM本身显示出显着的家族聚集性，暗示这种类型的血液肿瘤的病因的重要性，也许MGUS在生殖系基因。(c)2006 Wiley-Liss，Inc.
A population-based case-control study was conducted to evaluate risk of developing multiple myeloma (MM) associated with personal history of autoimmune diseases and occurrence of autoimmune and selected hematologic disorders in first-degree relatives. Data were obtained for all (n = 8,406) MM cases diagnosed in Sweden (1958-1998), with linkable relatives, 16,543 matched controls and first-degree relatives of cases (n = 22,490) and controls (it = 44,436). Odds ratios (ORs) were calculated to quantify the risk of MM in relation to personal/family history of 32 autoimmune disorders. Familial aggregation of malignancies was evaluated in a marginal survival model using relatives as the cohort. The risk for MM was significantly elevated among subjects with a personal history of pernicious anemia (OR = 3.27; 2.22-4.83) and individuals with a family history of systemic lupus erythematosus (OR = 2.66; 1.12-6.32). Compared with controls, relative risk (RR) of MM was significantly increased (RR = 1.67; 1.02-2.73) in relatives of cases, particularly relatives of probands aged >= 65 at diagnosis (RR = 2.50; 1.19-5.27). Risks were nearly 4-fold elevated among female relatives (RR = 3.97; 1.54-10.2) and among relatives of female probands (RR = 3.74; 1.58-8.83). MM cases had more cases of monoclonal gammopathy of undetermined significance (MGUS) among their relatives than controls, but the numbers were too small to be conclusive. There was generally no increase in risk of MM in probands whose relatives had hematologic malignancies other than MM. These findings do not support a strong association between personal/familial autoimmune diseases and MM. However, MM itself shows significant familial aggregation, implicating the etiologic importance of this type of hematological neoplasm and perhaps MGUS in germ line genes. (c) 2006 Wiley-Liss, Inc.