Role of TLR1 and TLR6 in the host defense against disseminated candidiasis
Role of TLR1 and TLR6 in the host defense against disseminated candidiasis
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DOI：
10.1111/j.1574-695x.2007.00353.x
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发表时间：
2008-01-01
影响因子：
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通讯作者：
Kullberg, Bart Jan
中科院分区：
文献类型：
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作者：
Netea, Mihai G.;van de Veerdonk, Frank;Kullberg, Bart Jan
toll样受体-1 （TLR1）和TLR6是TLR家族的受体，与TLR2形成异源二聚体。研究了TLR1和TLR6在真菌病原白色念珠菌识别中的作用。TLR1不参与白色念珠菌的识别，TLR1敲除（TLR1-/-）小鼠对播散性念珠菌病表现出正常的易感性。相反，TLR6对白色念珠菌的识别调节了Th1和Th2细胞因子之间的平衡，TLR6敲除小鼠表现出IL-10产生缺陷和ifn - γ释放增加。在TLR6-/-小鼠中，单核细胞来源的细胞因子肿瘤坏死因子、IL-1和IL-6的产生是正常的，并伴有对播散性念珠菌病的正常易感性。综上所述，TLR6参与白色念珠菌的识别并调节Th1/Th2细胞因子平衡，但这导致TLR6-/-小鼠的表型较轻，对念珠菌感染的易感性正常。
Toll-like receptor-1 (TLR1) and TLR6 are receptors of the TLR family that form heterodimers with TLR2. The role of TLR1 and TLR6 for the recognition of the fungal pathogen Candida albicans was investigated. TLR1 is not involved in the recognition of C. albicans, and TLR1 knock-out (TLR1-/-) mice showed a normal susceptibility to disseminated candidiasis. In contrast, recognition of C. albicans by TLR6 modulated the balance between Th1 and Th2 cytokines, and TLR6 knock-out mice displayed a defective production of IL-10 and an increased IFN-gamma release. Production of the monocyte-derived cytokines tumor necrosis factor, IL-1, and IL-6 was normal in TLR6-/- mice, and this was accompanied by a normal susceptibility to disseminated candidiasis. In conclusion, TLR6 is involved in the recognition of C. albicans and modulates the Th1/Th2 cytokine balance, but this results in a mild phenotype with a normal susceptibility of TLR6-/- mice to Candida infection.