Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation
Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation
复制标题
DOI：
10.3389/fimmu.2019.02148
复制
发表时间：
2019-10-24
影响因子：
7.3
通讯作者：
Levi, Benjamin
中科院分区：
文献类型：
--
作者：
Agarwal, Shailesh;Loder, Shawn J.;Levi, Benjamin
创伤后的炎症对正常伤口愈合至关重要，并且在延长或不受抑制时可能是高度有害的，具有损害生理愈合和促进新发病理的潜力。创伤后的机械应变与受损的伤口愈合和增加的炎症有关。这背后的确切机制尚未完全阐明。中性粒细胞细胞外陷阱（NET）是中性粒细胞对创伤反应的组成部分，与一系列促炎性疾病有关。在目前的研究中，我们评估了它们在连接运动和炎症中的作用。我们发现NET的破坏和扩增之间存在联系，NET具有调节伤口对机械应变的反应的潜力，同时保持生理伤口愈合所需的初始炎症信号完整。
Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is associated with impaired wound healing and increased inflammation. The exact mechanisms behind this are not fully elucidated. Neutrophil extracellular traps (NETs), a component of the neutrophil response to trauma, are implicated in a range of pro-inflammatory conditions. In the current study, we evaluated their role in linking movement and inflammation. We found that a link exists between the disruption and amplification of NETs which harbors the potential to regulate the wound's response to mechanical strain, while leaving the initial inflammatory signal necessary for physiologic wound healing intact.