Absence of albumin in tissues of analbuminemic rats.
Absence of albumin in tissues of analbuminemic rats.
复制标题
无白蛋白血症大鼠的组织中缺乏白蛋白。
DOI：
10.1093/oxfordjournals.jbchem.a133110
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
S. Nagase
中科院分区：
文献类型：
--
作者：
K. Sugiyama;T. Emori;S. Nagase
长酶无球蛋白血症大鼠（NAR）血清白蛋白缺乏。采用免疫荧光染色法检测大鼠血管外组织白蛋白含量。在NAR测试的任何组织（肝、肾、肌肉、皮肤和小肠）中均未检测到白蛋白，而在正常大鼠的所有这些组织中都清楚地显示出白蛋白。此外，NAR组织的提取物，包括肝脏，不含白蛋白检测单一径向免疫扩散法。这些发现表明，白蛋白不存在于NAR组织的血清或血管外区域，并提示NAR血清白蛋白缺乏不是由于肝脏白蛋白分泌受损或白蛋白在某些组织中的组织分布改变，而是由于其在肝脏中缺乏合成。
Nagase analbuminemic rats (NAR) are deficient in serum albumin. Extravascular regions of the tissues of NAR were tested for rat serum albumin by the immunofluorescence staining technique. Albumin was not detectable in any of the tissues of NAR tested (liver, kidney, muscle, skin, and small intestine), whereas it was clearly demonstrated in all these tissues of normal rats. Furthermore, extracts of NAR tissues, including the liver, contained no albumin detectable by the single radial immunodiffusion method. These findings indicate that albumin is not present in either the serum or extravascular regions of tissues of NAR, and suggest that the deficiency of serum albumin in NAR is not due to impaired albumin secretion from the liver or alteration of the tissue distribution of albumin in certain tissues, but to the absence of its synthesis in the liver.