And I hope you like jamming too.
And I hope you like jamming too.
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我希望你也喜欢即兴演奏。
DOI：
10.1088/1367-2630/17/9/091001
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发表时间：
2015
影响因子：
3.3
通讯作者：
Fredberg,JeffreyJ
中科院分区：
文献类型：
--
作者：
Tambe,DhananjayT;Fredberg,JeffreyJ
将明显不同的细胞类型分选到特定的组织区室中长期以来被认为是使不混溶流体中的总自由能最小化的问题，其中细胞-细胞粘附、细胞硬度和细胞收缩联合收割机组合以限定有效的宏观组织表面张力。Pawlizak等人（2015 New J. Phys. 17 083049）现在不仅表明界面处的粘附力意外地未能与粘附分子的密度相关，而且某些癌细胞系意外地未能表现为流体，细胞在动力学上陷入可能是堵塞的固体样非平衡状态。
The sorting of distinctly different cell types into specific tissue compartments has long been thought to be a problem in minimization of total free energy in immiscible fluids, wherein cell–cell adhesion, cell stiffness, and cell contraction combine to define an effective macroscopic tissue surface tension. Pawlizak et al (2015 New J. Phys. 17 083049) now show not only that adhesion forces at interfaces unexpectedly fail to correlate with the density of adhesion molecules, but also that certain cancer cell lines unexpectedly fail to behave as a fluid, with cells becoming kinetically trapped in what might be a jammed, solid-like non-equilibrium state.